Pharmacokinetics of rebaudioside A and stevioside after single oral doses in healthy men
- PMID: 18555578
- DOI: 10.1016/j.fct.2008.04.041
Pharmacokinetics of rebaudioside A and stevioside after single oral doses in healthy men
Abstract
This randomized, double-blind, cross-over study assessed the comparative pharmacokinetics of steviol and steviol glucuronide following single oral doses of rebaudioside A and stevioside in healthy adult male subjects. Steviol glucuronide appeared in the plasma of all subjects after administration of rebaudioside A or stevioside, with median tmax values of 12.0 and 8.00h post-dose, respectively. Steviol glucuronide was eliminated from the plasma, with similar t1/2 values of approximately 14h for both compounds. Administration of rebaudioside A resulted in a significantly (approximately 22%) lower steviol glucuronide geometric mean Cmax value (1472ng/mL) than administration of stevioside (1886ng/mL). The geometric mean AUC0-t value for steviol glucuronide after administration of rebaudioside A (30,788ngh/mL) was approximately 10% lower than after administration of stevioside (34,090ngh/mL). Steviol glucuronide was excreted primarily in the urine of the subjects during the 72h collection period, accounting for 59% and 62% of the rebaudioside A and stevioside doses, respectively. No steviol glucuronide was detected in feces. Pharmacokinetic analysis indicated that rebaudioside A and stevioside underwent similar metabolic and elimination pathways in humans with steviol glucuronide excreted primarily in the urine and steviol in the feces. No safety concerns were noted as determined by reporting of adverse events, laboratory assessments of safety or vital signs.
Similar articles
-
Comparative toxicokinetics and metabolism of rebaudioside A, stevioside, and steviol in rats.Food Chem Toxicol. 2008 Jul;46 Suppl 7:S31-9. doi: 10.1016/j.fct.2008.05.006. Epub 2008 May 16. Food Chem Toxicol. 2008. PMID: 18562068
-
Metabolism of stevioside by healthy subjects.Exp Biol Med (Maywood). 2007 Jan;232(1):164-73. Exp Biol Med (Maywood). 2007. PMID: 17202597
-
Metabolism of stevioside by chickens.J Agric Food Chem. 2003 Feb 12;51(4):1095-101. doi: 10.1021/jf020835o. J Agric Food Chem. 2003. PMID: 12568579
-
Microbial hydrolysis of steviol glycosides.Food Chem Toxicol. 2008 Jul;46 Suppl 7:S70-4. doi: 10.1016/j.fct.2008.05.008. Epub 2008 May 16. Food Chem Toxicol. 2008. PMID: 18550247 Review.
-
Stevioside and related compounds: therapeutic benefits beyond sweetness.Pharmacol Ther. 2009 Jan;121(1):41-54. doi: 10.1016/j.pharmthera.2008.09.007. Epub 2008 Oct 27. Pharmacol Ther. 2009. PMID: 19000919 Review.
Cited by
-
Steviol Glycosides from Stevia rebaudiana: An Updated Overview of Their Sweetening Activity, Pharmacological Properties, and Safety Aspects.Molecules. 2023 Jan 27;28(3):1258. doi: 10.3390/molecules28031258. Molecules. 2023. PMID: 36770924 Free PMC article. Review.
-
Early Life Low-Calorie Sweetener Consumption Impacts Energy Balance during Adulthood.Nutrients. 2022 Nov 8;14(22):4709. doi: 10.3390/nu14224709. Nutrients. 2022. PMID: 36432396 Free PMC article.
-
Early-life low-calorie sweetener consumption disrupts glucose regulation, sugar-motivated behavior, and memory function in rats.JCI Insight. 2022 Oct 24;7(20):e157714. doi: 10.1172/jci.insight.157714. JCI Insight. 2022. PMID: 36099052 Free PMC article.
-
Pharmacokinetics of Oral Rebaudioside A in Patients with Type 2 Diabetes Mellitus and Its Effects on Glucose Homeostasis: A Placebo-Controlled Crossover Trial.Eur J Drug Metab Pharmacokinet. 2022 Nov;47(6):827-839. doi: 10.1007/s13318-022-00792-7. Epub 2022 Sep 3. Eur J Drug Metab Pharmacokinet. 2022. PMID: 36057030 Free PMC article. Clinical Trial.
-
Artificial Sweeteners: History and New Concepts on Inflammation.Front Nutr. 2021 Sep 24;8:746247. doi: 10.3389/fnut.2021.746247. eCollection 2021. Front Nutr. 2021. PMID: 34631773 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources