The effect of social environment on markers of vascular oxidative stress and inflammation in the Watanabe heritable hyperlipidemic rabbit
- PMID: 18256340
- DOI: 10.1097/PSY.0b013e3181646753
The effect of social environment on markers of vascular oxidative stress and inflammation in the Watanabe heritable hyperlipidemic rabbit
Abstract
Objective: Previous research demonstrated that social environment can influence progression of atherosclerosis in the Watanabe Heritable Hyperlipidemic (WHHL) rabbit. This study examined the effect of social environment on markers of oxidative stress and inflammation to clarify the physiological pathways potentially responsible for the influence of social environment on disease.
Methods and results: WHHL rabbits were assigned to 1 of 3 social groups: an unstable group, in which unfamiliar rabbits were paired daily, with the pairing switched each week; a stable group, in which littermates were paired daily; and an individually-caged group. The stable group engaged in more affiliative social behavior than the unstable group. The unstable group showed more agonistic behavior compared with the stable group and higher C-reactive protein levels than the individually caged group. The individually caged group was behaviorally sedentary, had higher 24-hour urinary catecholamine levels than the other groups, and exhibited higher NAD(P)H-oxidase activity in the aortic arch relative to the stable group.
Conclusions: The results suggest that social environment creates distinct behavioral contexts that can affect markers of inflammation and oxidative stress early in the development of atherosclerosis. Specifically, physical inactivity associated with individual caging affects indices of oxidative stress and inflammation. These pathophysiological markers may help to explain behaviorally related differences in the extent of atherosclerosis observed in prior studies.
Similar articles
-
Structural Remodeling of Sympathetic Innervation in Atherosclerotic Blood Vessels: Role of Atherosclerotic Disease Progression and Chronic Social Stress.Psychosom Med. 2017 Jan;79(1):59-70. doi: 10.1097/PSY.0000000000000360. Psychosom Med. 2017. PMID: 27359178 Free PMC article.
-
The influence of social environment on endocrine, cardiovascular and tissue responses in the rabbit.Int J Psychophysiol. 2013 Jun;88(3):282-8. doi: 10.1016/j.ijpsycho.2012.04.008. Epub 2012 Apr 27. Int J Psychophysiol. 2013. PMID: 22546665 Free PMC article.
-
The Watanabe heritable hyperlipidemic (WHHL) rabbit, its characteristics and history of development: a tribute to the late Dr. Yoshio Watanabe.Atherosclerosis. 2009 Nov;207(1):1-7. doi: 10.1016/j.atherosclerosis.2009.03.024. Epub 2009 Apr 1. Atherosclerosis. 2009. PMID: 19389675 Review.
-
Social experience influences hypothalamic oxytocin in the WHHL rabbit.Psychoneuroendocrinology. 2006 Oct;31(9):1062-75. doi: 10.1016/j.psyneuen.2006.06.007. Epub 2006 Sep 11. Psychoneuroendocrinology. 2006. PMID: 16963189
-
Social environment influences the progression of atherosclerosis in the watanabe heritable hyperlipidemic rabbit.Circulation. 2002 Jan 22;105(3):354-9. doi: 10.1161/hc0302.102144. Circulation. 2002. PMID: 11804992
Cited by
-
Social support and C-reactive protein in a Québec population cohort of children and adolescents.PLoS One. 2022 Jun 22;17(6):e0268210. doi: 10.1371/journal.pone.0268210. eCollection 2022. PLoS One. 2022. PMID: 35731783 Free PMC article.
-
Association of Intensive Blood Pressure Control and Living Arrangement on Cardiovascular Outcomes by Race: Post Hoc Analysis of SPRINT Randomized Clinical Trial.JAMA Netw Open. 2022 Mar 1;5(3):e222037. doi: 10.1001/jamanetworkopen.2022.2037. JAMA Netw Open. 2022. PMID: 35285922 Free PMC article. Clinical Trial.
-
Chronic Stress A Potential Suspect Zero of Atherosclerosis: A Systematic Review.Front Cardiovasc Med. 2021 Dec 20;8:738654. doi: 10.3389/fcvm.2021.738654. eCollection 2021. Front Cardiovasc Med. 2021. PMID: 34988123 Free PMC article.
-
The role of oxidative stress in cardiovascular disease caused by social isolation and loneliness.Redox Biol. 2020 Oct;37:101585. doi: 10.1016/j.redox.2020.101585. Epub 2020 Jul 16. Redox Biol. 2020. PMID: 32709420 Free PMC article. Review.
-
Friends With Health Benefits: The Long-Term Benefits of Early Peer Social Integration for Blood Pressure and Obesity in Midlife.Psychol Sci. 2018 May;29(5):814-823. doi: 10.1177/0956797617746510. Epub 2018 Mar 13. Psychol Sci. 2018. PMID: 29533704 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Research Materials