Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study
- PMID: 18221932
- DOI: 10.1016/j.ajog.2007.10.803
Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study
Abstract
Objective: The objective of the study was to examine whether the risk of miscarriage is associated with caffeine consumption during pregnancy after controlling for pregnancy-related symptoms.
Study design: This was a population-based prospective cohort study.
Results: An increasing dose of daily caffeine intake during pregnancy was associated with an increased risk of miscarriage, compared with no caffeine intake, with an adjusted hazard ratio (aHR) of 1.42 (95% confidence interval 0.93 to 2.15) for caffeine intake of less than 200 mg/day, and aHR of 2.23 (1.34 to 3.69) for intake of 200 or more mg/day, respectively. Nausea or vomiting during pregnancy did not materially affect this observed association, nor did the change in intake pattern of caffeine during pregnancy. In addition, the magnitude of the association appeared to be stronger among women without a history of miscarriage (aHR 2.33, 1.48 to 3.67) than that among women with such a history (aHR 0.81, 0.34 to 1.94).
Conclusion: Our results demonstrated that high doses of caffeine intake during pregnancy increase the risk of miscarriage, independent of pregnancy-related symptoms.
Comment in
-
Maternal caffeine consumption during pregnancy and the risk of miscarriage.Am J Obstet Gynecol. 2008 Nov;199(5):e13; author reply e13-4. doi: 10.1016/j.ajog.2008.05.031. Epub 2008 Jul 29. Am J Obstet Gynecol. 2008. PMID: 18667176 No abstract available.
-
Caffeine and miscarriage: case closed?Am J Obstet Gynecol. 2008 Nov;199(5):e14-5. doi: 10.1016/j.ajog.2008.05.033. Epub 2008 Jul 29. Am J Obstet Gynecol. 2008. PMID: 18667179 No abstract available.
-
Is caffeine use during pregnancy really unsafe?Am J Obstet Gynecol. 2008 Nov;199(5):e16. doi: 10.1016/j.ajog.2008.05.035. Epub 2008 Aug 8. Am J Obstet Gynecol. 2008. PMID: 18691688 Free PMC article. No abstract available.
-
Caffeine in miscarriages: it's not just in the coffee.Am J Obstet Gynecol. 2008 Nov;199(5):e15. doi: 10.1016/j.ajog.2008.05.034. Am J Obstet Gynecol. 2008. PMID: 18984072 No abstract available.
Similar articles
-
A meta-analysis of risk of pregnancy loss and caffeine and coffee consumption during pregnancy.Int J Gynaecol Obstet. 2015 Aug;130(2):116-22. doi: 10.1016/j.ijgo.2015.03.033. Epub 2015 May 14. Int J Gynaecol Obstet. 2015. PMID: 26026343 Review.
-
Risks of repeated miscarriage.Paediatr Perinat Epidemiol. 2006 Mar;20(2):119-26. doi: 10.1111/j.1365-3016.2006.00703.x. Paediatr Perinat Epidemiol. 2006. PMID: 16466430
-
Maternal caffeine consumption and fetal death: a case-control study in Uruguay.Paediatr Perinat Epidemiol. 2006 Mar;20(2):100-9. doi: 10.1111/j.1365-3016.2006.00706.x. Paediatr Perinat Epidemiol. 2006. PMID: 16466428
-
Effects of caffeine on human health.Food Addit Contam. 2003 Jan;20(1):1-30. doi: 10.1080/0265203021000007840. Food Addit Contam. 2003. PMID: 12519715 Review.
-
Caffeine intake and the risk of first-trimester spontaneous abortion.N Engl J Med. 2000 Dec 21;343(25):1839-45. doi: 10.1056/NEJM200012213432503. N Engl J Med. 2000. PMID: 11117975
Cited by
-
Understanding trimester-specific miscarriage risk in Indian women: insights from the calendar data of National Family Health Survey (NFHS-5) 2019-21.BMC Womens Health. 2024 Jan 23;24(1):63. doi: 10.1186/s12905-023-02838-7. BMC Womens Health. 2024. PMID: 38263129 Free PMC article.
-
Determinants of neural tube defects among newborns in public referral hospitals in Eastern Ethiopia.BMC Nutr. 2023 Jul 25;9(1):93. doi: 10.1186/s40795-023-00752-7. BMC Nutr. 2023. PMID: 37491389 Free PMC article.
-
Lipid-Lowering Nutraceuticals for an Integrative Approach to Dyslipidemia.J Clin Med. 2023 May 11;12(10):3414. doi: 10.3390/jcm12103414. J Clin Med. 2023. PMID: 37240523 Free PMC article. Review.
-
Relationship between maternal caffeine and coffee intake and pregnancy loss: A grading of recommendations assessment, development, and evaluation-assessed, dose-response meta-analysis of observational studies.Front Nutr. 2022 Aug 9;9:886224. doi: 10.3389/fnut.2022.886224. eCollection 2022. Front Nutr. 2022. PMID: 36017225 Free PMC article.
-
Update and New Insights on Future Cancer Drug Candidates From Plant-Based Alkaloids.Front Pharmacol. 2021 Dec 16;12:719694. doi: 10.3389/fphar.2021.719694. eCollection 2021. Front Pharmacol. 2021. PMID: 34975465 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical