Functions and dysfunctions of mitochondrial dynamics
- PMID: 17928812
- DOI: 10.1038/nrm2275
Functions and dysfunctions of mitochondrial dynamics
Abstract
Recent findings have sparked renewed appreciation for the remarkably dynamic nature of mitochondria. These organelles constantly fuse and divide, and are actively transported to specific subcellular locations. These dynamic processes are essential for mammalian development, and defects lead to neurodegenerative disease. But what are the molecular mechanisms that control mitochondrial dynamics, and why are they important for mitochondrial function? We review these issues and explore how defects in mitochondrial dynamics might cause neuronal disease.
Similar articles
-
Mitochondrial trafficking in neuropsychiatric diseases.Neurobiol Dis. 2013 Mar;51:66-71. doi: 10.1016/j.nbd.2012.06.015. Epub 2012 Jun 30. Neurobiol Dis. 2013. PMID: 22750523 Review.
-
A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases.J Cell Sci. 2007 May 15;120(Pt 10):1707-16. doi: 10.1242/jcs.03443. J Cell Sci. 2007. PMID: 17502481 Review.
-
Mitochondrial trafficking and morphology in healthy and injured neurons.Prog Neurobiol. 2006 Dec;80(5):241-68. doi: 10.1016/j.pneurobio.2006.09.003. Epub 2006 Dec 26. Prog Neurobiol. 2006. PMID: 17188795 Review.
-
What role does mitochondrial stress play in neurodegenerative diseases?Methods Mol Biol. 2010;648:63-78. doi: 10.1007/978-1-60761-756-3_4. Methods Mol Biol. 2010. PMID: 20700705 Review.
-
Regulation of mitochondrial fusion and division.Trends Cell Biol. 2007 Nov;17(11):563-9. doi: 10.1016/j.tcb.2007.08.006. Epub 2007 Oct 23. Trends Cell Biol. 2007. PMID: 17959383 Review.
Cited by
-
Chondrocyte-targeted exosome-mediated delivery of Nrf2 alleviates cartilaginous endplate degeneration by modulating mitochondrial fission.J Nanobiotechnology. 2024 May 24;22(1):281. doi: 10.1186/s12951-024-02517-1. J Nanobiotechnology. 2024. PMID: 38790015 Free PMC article.
-
Resilience to diabetic retinopathy.Prog Retin Eye Res. 2024 Jul;101:101271. doi: 10.1016/j.preteyeres.2024.101271. Epub 2024 May 11. Prog Retin Eye Res. 2024. PMID: 38740254 Free PMC article. Review.
-
Socialized mitochondria: mitonuclear crosstalk in stress.Exp Mol Med. 2024 May;56(5):1033-1042. doi: 10.1038/s12276-024-01211-4. Epub 2024 May 1. Exp Mol Med. 2024. PMID: 38689084 Free PMC article. Review.
-
Nicotinamide Mononucleotide and Nicotinamide Riboside Reverse Ovarian Aging in Rats Via Rebalancing Mitochondrial Fission and Fusion Mechanisms.Pharm Res. 2024 May;41(5):921-935. doi: 10.1007/s11095-024-03704-3. Epub 2024 Apr 29. Pharm Res. 2024. PMID: 38684562 Free PMC article.
-
Skeletal muscle dysfunction in amyotrophic lateral sclerosis: a mitochondrial perspective and therapeutic approaches.Neurol Sci. 2024 Apr 27. doi: 10.1007/s10072-024-07508-6. Online ahead of print. Neurol Sci. 2024. PMID: 38676818 Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources