Effect of fluoxetine alone and in combination with sildenafil in patients with premature ejaculation
- PMID: 17627164
- DOI: 10.1159/000102909
Effect of fluoxetine alone and in combination with sildenafil in patients with premature ejaculation
Abstract
Introduction: The aim of this study was to compare the efficacy of fluoxetine alone and combined with sildenafil in patients complaining of premature ejaculation.
Patients and methods: Ninety-one married potent men, 21-43 years old, with premature ejaculation but without any obvious organic cause were enrolled. Pretreatment evaluation included history, physical examination, and self-administration of the International Index of Erectile Function questionnaire. The patients were randomly divided into two groups: group A patients (n = 48) received 20 mg fluoxetine daily for 4 weeks and then 20 mg as needed 2-3 h before sexual activity for 4 months, and group B patients (n = 43) received group A regimen plus 50 mg sildenafil as needed 1 h before sexual activity for 4 months.
Results: Ejaculatory latency time and intercourse satisfaction significantly improved in group B as compared with group A (p < 0.05).
Conclusion: Fluoxetine combined with sildenafil seems to provide significantly better ejaculatory latency time and intercourse satisfaction as compared with fluoxetine alone in patients with premature ejaculation.
Similar articles
-
Selective serotonin reuptake inhibitors in the treatment of premature ejaculation.Chin Med J (Engl). 2007 Jun 5;120(11):1000-6. Chin Med J (Engl). 2007. PMID: 17624269 Review.
-
Can sildenafil treat primary premature ejaculation? A prospective clinical study.Int J Urol. 2007 Apr;14(4):331-5. doi: 10.1111/j.1442-2042.2007.01606.x. Int J Urol. 2007. PMID: 17470165 Clinical Trial.
-
[Male sexual dysfunction involving penile erection, emission and ejaculation].Nihon Rinsho. 2006 Jun 28;Suppl 2:279-83. Nihon Rinsho. 2006. PMID: 16817403 Review. Japanese. No abstract available.
-
Efficacy of sildenafil as adjuvant therapy to selective serotonin reuptake inhibitor in alleviating premature ejaculation.Urology. 2003 Jan;61(1):197-200. doi: 10.1016/s0090-4295(02)02075-7. Urology. 2003. PMID: 12559295
-
A prospective study comparing paroxetine alone versus paroxetine plus sildenafil in patients with premature ejaculation.J Urol. 2002 Dec;168(6):2486-9. doi: 10.1016/S0022-5347(05)64174-2. J Urol. 2002. PMID: 12441946
Cited by
-
Combined on-demand sildenafil citrate and tramadol hydrochloride is an effective and safe treatment for premature ejaculation: A randomized placebo-controlled double-blind clinical trial.Arab J Urol. 2023 Nov 30;22(2):89-95. doi: 10.1080/20905998.2023.2287869. eCollection 2024. Arab J Urol. 2023. PMID: 38481408 Free PMC article.
-
An update on the treatment of premature ejaculation: A systematic review.Arab J Urol. 2021 Aug 4;19(3):281-302. doi: 10.1080/2090598X.2021.1943273. eCollection 2021. Arab J Urol. 2021. PMID: 34552780 Free PMC article. Review.
-
Off-label Uses of Selective Serotonin Reuptake Inhibitors (SSRIs).Curr Neuropharmacol. 2022;20(4):693-712. doi: 10.2174/1570159X19666210517150418. Curr Neuropharmacol. 2022. PMID: 33998993 Free PMC article. Review.
-
Selective serotonin re-uptake inhibitors for premature ejaculation in adult men.Cochrane Database Syst Rev. 2021 Mar 21;3(3):CD012799. doi: 10.1002/14651858.CD012799.pub2. Cochrane Database Syst Rev. 2021. PMID: 33745183 Free PMC article.
-
Effectiveness comparisons of Chinese patent medicine on treating premature ejaculation: A systematic review and meta-analysis.Medicine (Baltimore). 2019 Nov;98(44):e17729. doi: 10.1097/MD.0000000000017729. Medicine (Baltimore). 2019. PMID: 31689816 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
