2756GG genotype of methionine synthase reductase gene is more prevalent in rheumatoid arthritis patients treated with methotrexate and is associated with methotrexate-induced nodulosis
- PMID: 17611986
2756GG genotype of methionine synthase reductase gene is more prevalent in rheumatoid arthritis patients treated with methotrexate and is associated with methotrexate-induced nodulosis
Abstract
Objective: To investigate the distribution of the A2756G polymorphism of the methionine synthase reductase (MTR) gene in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX) compared with a healthy control group; and to examine the relationships among the A2756G polymorphism, plasma total homocysteine (tHcy), serum folate and vitamin B12 levels, disease activity, and MTX toxicity in patients with RA.
Methods: A cross-sectional study was performed on 86 MTX-treated RA patients, consisting of a clinical interview and physical examination to determine disease activity and MTX-related adverse reactions. Genotype analysis of the MTR gene was performed. Fasting plasma tHcy, serum folate, and vitamin B12 levels were measured. Allele and genotype distributions were compared to a healthy control group.
Results: The frequency of the 2756GG genotype (16.3%) in the RA study group was higher than that expected in the general population (3.6%; p < 0.000001). This genotype was associated with MTX-induced accelerated rheumatoid nodulosis (MIARN). No association of disease activity variables or plasma homocysteine with MTR A2756G polymorphisms was observed. The MTR 2756GG genotype, low plasma vitamin B12 levels, and the presence of rheumatoid nodules predicted MIARN. No association of nodulosis with any other indicator of disease activity or medical treatment was found.
Conclusion: In our population of MTX-treated RA patients the 2756GG genotype of the MTR gene was more common than expected and was associated with MIARN.
Similar articles
-
Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene.Ann Rheum Dis. 2004 Oct;63(10):1227-31. doi: 10.1136/ard.2003.016337. Ann Rheum Dis. 2004. PMID: 15361376 Free PMC article.
-
Reduced folate carrier-1 80G>A polymorphism affects methotrexate treatment outcome in rheumatoid arthritis.Pharmacogenomics J. 2007 Dec;7(6):404-7. doi: 10.1038/sj.tpj.6500438. Epub 2007 Feb 27. Pharmacogenomics J. 2007. PMID: 17325736 Clinical Trial.
-
Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentred cross sectional observational study.Ann Rheum Dis. 2005 Aug;64(8):1180-5. doi: 10.1136/ard.2004.033399. Epub 2005 Jan 27. Ann Rheum Dis. 2005. PMID: 15677700 Free PMC article.
-
Folate supplementation and methotrexate treatment in rheumatoid arthritis: a review.Rheumatology (Oxford). 2004 Mar;43(3):267-71. doi: 10.1093/rheumatology/keh088. Epub 2004 Jan 6. Rheumatology (Oxford). 2004. PMID: 14963199 Review.
-
Two cases of methotrexate induced lymphomas in rheumatoid arthritis: an association with increased serum IgE.J Rheumatol. 1999 Oct;26(10):2249-53. J Rheumatol. 1999. PMID: 10529149 Review.
Cited by
-
Methotrexate-Induced Accelerated Nodulosis in a Patient with Systemic Lupus Erythematosus.Ann Dermatol. 2023 Nov;35(Suppl 2):S272-S274. doi: 10.5021/ad.21.312. Ann Dermatol. 2023. PMID: 38061720 Free PMC article.
-
Cutaneous Manifestations of Rheumatoid Arthritis: Diagnosis and Treatment.J Pers Med. 2023 Oct 10;13(10):1479. doi: 10.3390/jpm13101479. J Pers Med. 2023. PMID: 37888090 Free PMC article. Review.
-
Rheumatoid Nodule Simulating a Parotid Tumor.Head Neck Pathol. 2021 Mar;15(1):334-340. doi: 10.1007/s12105-020-01175-7. Epub 2020 May 20. Head Neck Pathol. 2021. PMID: 32436170 Free PMC article.
-
Are gene polymorphisms related to adverse events of methotrexate in patients with rheumatoid arthritis? A retrospective cohort study based on an updated meta-analysis.Ther Adv Chronic Dis. 2020 Apr 27;11:2040622320916026. doi: 10.1177/2040622320916026. eCollection 2020. Ther Adv Chronic Dis. 2020. PMID: 32426102 Free PMC article.
-
Accelerated subcutaneous nodulosis in patients with rheumatoid arthritis treated with tocilizumab: a case series.J Med Case Rep. 2018 Jun 3;12(1):154. doi: 10.1186/s13256-018-1687-y. J Med Case Rep. 2018. PMID: 29859543 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases