OMERACT/OARSI initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis
- PMID: 17552070
OMERACT/OARSI initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis
Abstract
Objective: Time to theoretical indication of joint replacement surgery has been proposed as a primary outcome for potential structure-modifying interventions for osteoarthritis (OA). The objectives of this OMERACT/OARSI Working Group were to identify pain, physical function, and structure states that represent the progression from early to late disease for individuals with OA of the hip and knee, and to create a composite measure of these 3 domains to define states of OA severity and a surrogate measure of "need for joint replacement surgery."
Methods: For pain, focus groups and one-on-one interviews were used. For function, Rasch analysis was performed on existing indices the Hip Dysfunction and Osteoarthritis Outcome Score (HOOS) and the Knee injury and Osteoarthritis Outcome Score (KOOS), each of which subsumes the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) questions. For structure, a comparison of existing indices (Kellgren-Lawrence, OARSI stages, and joint space width) was performed for the hip and the knee.
Results: For pain, key features of pain that are most distressing to people with OA from early to late disease were identified. For function, the reduction of the number of items based on the existing indices continues. For structure, the analysis is also ongoing.
Conclusion: Preliminary results were presented at OMERACT 8; the final objective will be to combine the 3 domains (pain, function, and structure) and to create a composite index that could define states of severity and "need for total joint replacement," which could be used to evaluate treatment response to disease-modifying drugs in OA clinical trials.
Similar articles
-
OARSI/OMERACT criteria of being considered a candidate for total joint replacement in knee/hip osteoarthritis as an endpoint in clinical trials evaluating potential disease modifying osteoarthritic drugs.J Rheumatol. 2009 Sep;36(9):2097-9. doi: 10.3899/jrheum.090365. J Rheumatol. 2009. PMID: 19738220
-
Joint replacement surgery in elderly patients with severe osteoarthritis of the hip or knee: decision making, postoperative recovery, and clinical outcomes.Arch Intern Med. 2008 Jul 14;168(13):1430-40. doi: 10.1001/archinte.168.13.1430. Arch Intern Med. 2008. PMID: 18625924
-
Validation of the Spanish version of the WOMAC questionnaire for patients with hip or knee osteoarthritis. Western Ontario and McMaster Universities Osteoarthritis Index.Clin Rheumatol. 2002 Nov;21(6):466-71. doi: 10.1007/s100670200117. Clin Rheumatol. 2002. PMID: 12447629
-
Outcome variables for osteoarthritis clinical trials: The OMERACT-OARSI set of responder criteria.J Rheumatol. 2003 Jul;30(7):1648-54. J Rheumatol. 2003. PMID: 12858473 Review.
-
Total joint replacement of hip or knee as an outcome measure for structure modifying trials in osteoarthritis.Osteoarthritis Cartilage. 2005 Jan;13(1):13-9. doi: 10.1016/j.joca.2004.10.012. Osteoarthritis Cartilage. 2005. PMID: 15639632 Review.
Cited by
-
FDA/Arthritis Foundation osteoarthritis drug development workshop recap: Assessment of long-term benefit.Semin Arthritis Rheum. 2022 Oct;56:152070. doi: 10.1016/j.semarthrit.2022.152070. Epub 2022 Jul 14. Semin Arthritis Rheum. 2022. PMID: 35870222 Free PMC article. Review.
-
Predictors of Effectiveness of Platelet-Rich Plasma Therapy for Knee Osteoarthritis: A Retrospective Cohort Study.J Clin Med. 2021 Sep 29;10(19):4514. doi: 10.3390/jcm10194514. J Clin Med. 2021. PMID: 34640529 Free PMC article.
-
Comparative meta-analysis of pyrocarbon and silicone for joint replacement surgery.Medicine (Baltimore). 2020 Oct 9;99(41):e22548. doi: 10.1097/MD.0000000000022548. Medicine (Baltimore). 2020. PMID: 33031299 Free PMC article.
-
Discordance between self-reported and performance-based function among knee osteoarthritis surgical patients: Variations by sex and obesity.PLoS One. 2020 Jul 30;15(7):e0236865. doi: 10.1371/journal.pone.0236865. eCollection 2020. PLoS One. 2020. PMID: 32730319 Free PMC article.
-
Effects of umbilical cord mesenchymal stem cells loaded with graphene oxide granular lubrication on cytokine levels in animal models of knee osteoarthritis.Int Orthop. 2021 Feb;45(2):381-390. doi: 10.1007/s00264-020-04584-z. Epub 2020 Jun 16. Int Orthop. 2021. PMID: 32556386
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical