Alterations in sperm motility after acute oral administration of sildenafil or tadalafil in young, infertile men
- PMID: 17544419
- DOI: 10.1016/j.fertnstert.2006.12.019
Alterations in sperm motility after acute oral administration of sildenafil or tadalafil in young, infertile men
Abstract
Objective: To evaluate the acute effect of sildenafil and tadalafil on seminal parameters in young, infertile patients.
Design: Prospective, randomized, double-blind, crossover clinical investigation on semen parameters after the administration of a single dose of sildenafil (50 mg) or tadalafil (20 mg).
Setting: An academic hospital as well as a male infertility center and clinical andrology laboratories.
Patient(s): Eighteen young, infertile men.
Intervention(s): Oral administration of a single dose of sildenafil (50 mg) or tadalafil (20 mg) in a blind, randomized order. The semen samples were collected 1 or 2 hours after each treatment.
Main outcome measure(s): Changes in sperm parameters after sildenafil and tadalafil administration, compared with the basal conditions.
Result(s): A significant increase in sperm progressive motility (median value, 37.0% vs. 28.5%) was observed after sildenafil administration as compared with baseline; in contrast, a significant decreased value was observed after tadalafil (median value, 21.5% vs. 28.5%).
Conclusion(s): These preliminary results indicate that sperm motility appears to be acutely affected in young, infertile patients by a single dose of sildenafil and tadalafil, with opposite effects: stimulatory by the former and inhibitory by the latter.
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