Complex trait genetics of refractive error
- PMID: 17210850
- DOI: 10.1001/archopht.125.1.38
Complex trait genetics of refractive error
Abstract
Refractive errors (myopia, hyperopia, and astigmatism) are complex heterogeneous disorders of the human eye and are ideal for genetic investigation. Moderate to severe refractive errors can predispose individuals to poor visual development, various types of glaucoma, misshapen corneal surfaces, premature cataracts, and loss of retinal integrity, which can lead to detachment. Knowledge of genetic mechanisms involved in refractive error susceptibility may allow treatment to prevent progression or to further examine gene-environment interactions. Early genetic predisposition detection for developing severe refractive errors may be useful for efficient and cost-effective screening program design. This review explores the genetic mechanisms associated with nonsyndromic refractive error development known to date.
Similar articles
-
Nature and nurture: the complex genetics of myopia and refractive error.Clin Genet. 2011 Apr;79(4):301-20. doi: 10.1111/j.1399-0004.2010.01592.x. Epub 2010 Dec 13. Clin Genet. 2011. PMID: 21155761 Free PMC article. Review.
-
Genetic susceptibility and mechanisms for refractive error.Clin Genet. 2013 Aug;84(2):102-8. doi: 10.1111/cge.12180. Epub 2013 Jun 10. Clin Genet. 2013. PMID: 23647423 Free PMC article. Review.
-
Support for polygenic influences on ocular refractive error.Invest Ophthalmol Vis Sci. 2005 Feb;46(2):442-6. doi: 10.1167/iovs.04-0794. Invest Ophthalmol Vis Sci. 2005. PMID: 15671267
-
Origins of Refractive Errors: Environmental and Genetic Factors.Annu Rev Vis Sci. 2019 Sep 15;5:47-72. doi: 10.1146/annurev-vision-091718-015027. Annu Rev Vis Sci. 2019. PMID: 31525141 Review.
-
The GEnes in Myopia (GEM) study in understanding the aetiology of refractive errors.Prog Retin Eye Res. 2010 Nov;29(6):520-42. doi: 10.1016/j.preteyeres.2010.05.004. Epub 2010 May 31. Prog Retin Eye Res. 2010. PMID: 20576483 Review.
Cited by
-
Case report: Mirror-image hypermetropic anisometropia in nontwin brothers.Oman J Ophthalmol. 2023 Oct 18;16(3):558-560. doi: 10.4103/ojo.ojo_52_23. eCollection 2023 Sep-Dec. Oman J Ophthalmol. 2023. PMID: 38059112 Free PMC article.
-
Whole-Exome Sequencing Among School-Aged Children With High Myopia.JAMA Netw Open. 2023 Dec 1;6(12):e2345821. doi: 10.1001/jamanetworkopen.2023.45821. JAMA Netw Open. 2023. PMID: 38039006 Free PMC article.
-
Effect of vascular endothelial growth factor 165 on dopamine level in the retinas of guinea pigs with form-deprivation myopia.PeerJ. 2023 Oct 13;11:e16255. doi: 10.7717/peerj.16255. eCollection 2023. PeerJ. 2023. PMID: 37849827 Free PMC article.
-
Endoplasmic reticulum stress: molecular mechanism and therapeutic targets.Signal Transduct Target Ther. 2023 Sep 15;8(1):352. doi: 10.1038/s41392-023-01570-w. Signal Transduct Target Ther. 2023. PMID: 37709773 Free PMC article. Review.
-
Clouclip combined with a questionnaire on the influence factors of myopia in children.Front Pediatr. 2023 Aug 7;11:1228257. doi: 10.3389/fped.2023.1228257. eCollection 2023. Front Pediatr. 2023. PMID: 37609361 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical