Review
doi: 10.1016/j.coph.2006.08.013.
Epub 2006 Nov 9.
NMDA receptors and schizophrenia
Affiliations
- PMID: 17097347
- DOI: 10.1016/j.coph.2006.08.013
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Review
NMDA receptors and schizophrenia
Curr Opin Pharmacol.
2007 Feb.
Abstract
The pathophysiology of schizophrenia is poorly understood but is likely to involve alterations in excitatory glutamatergic signaling molecules in several areas of the brain. Clinical and experimental evidence has shown that expression of the N-methyl-D-aspartate (NMDA) receptor and intracellular NMDA receptor-interacting proteins of the glutaminergic synapse appear to be dysregulated in schizophrenia. It has been suggested that schizophrenia involves molecular changes in the glutamatergic pathways that mediate excitatory communication between multiple brain regions. Recent data also implicate abnormalities in cellular functions such as receptor trafficking and synaptic targeting.
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