Selection of the cutaneous intraepithelial gammadelta+ T cell repertoire by a thymic stromal determinant
- PMID: 16829962
- DOI: 10.1038/ni1363
Selection of the cutaneous intraepithelial gammadelta+ T cell repertoire by a thymic stromal determinant
Abstract
Intraepithelial lymphocytes constitute a group of T cells that express mainly monospecific or oligoclonal T cell receptors (TCRs). Like adaptive TCR alphabeta+ T cells, intraepithelial lymphocytes, a subset enriched in TCR gammadelta+ T cells, are proposed to be positively selected by thymically expressed self agonists, yet no direct evidence for this exists at present. Mouse dendritic epidermal T cells are prototypic intraepithelial lymphocytes, displaying an almost monoclonal TCR gammadelta+ repertoire. Here we describe an FVB substrain of mice in which this repertoire was uniquely depleted, resulting in cutaneous pathology. This phenotype was due to failure of dendritic epidermal T cell progenitors to mature because of a heritable defect in a dominant gene used by the thymic stroma to 'educate' the natural, skin-associated intraepithelial lymphocyte repertoire to be of physiological use.
Comment in
-
Selection of intraepithelial gammadelta cells: the Holy GrIEL at last?Nat Immunol. 2006 Aug;7(8):791-2. doi: 10.1038/ni0806-791. Nat Immunol. 2006. PMID: 16855600 No abstract available.
Similar articles
-
Lineage divergence at the first TCR-dependent checkpoint: preferential γδ and impaired αβ T cell development in nonobese diabetic mice.J Immunol. 2011 Jan 15;186(2):826-37. doi: 10.4049/jimmunol.1002630. Epub 2010 Dec 10. J Immunol. 2011. PMID: 21148803 Free PMC article.
-
Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes.Nat Immunol. 2012 Apr 1;13(5):511-8. doi: 10.1038/ni.2247. Nat Immunol. 2012. PMID: 22473038 Free PMC article.
-
Selection of intraepithelial gammadelta cells: the Holy GrIEL at last?Nat Immunol. 2006 Aug;7(8):791-2. doi: 10.1038/ni0806-791. Nat Immunol. 2006. PMID: 16855600 No abstract available.
-
gammadelta T cell subsets: a link between TCR and function?Semin Immunol. 2010 Aug;22(4):193-8. doi: 10.1016/j.smim.2010.03.006. Epub 2010 May 6. Semin Immunol. 2010. PMID: 20451408 Free PMC article. Review.
-
Skin gammadelta T-cell functions in homeostasis and wound healing.Immunol Rev. 2007 Feb;215:114-22. doi: 10.1111/j.1600-065X.2006.00483.x. Immunol Rev. 2007. PMID: 17291283 Review.
Cited by
-
γδ T cells as immunotherapy for malaria: balancing challenges and opportunities.Front Immunol. 2023 Dec 6;14:1242306. doi: 10.3389/fimmu.2023.1242306. eCollection 2023. Front Immunol. 2023. PMID: 38124746 Free PMC article. No abstract available.
-
Tick extracellular vesicles impair epidermal homeostasis through immune-epithelial networks during hematophagy.bioRxiv [Preprint]. 2023 Nov 10:2023.11.10.566612. doi: 10.1101/2023.11.10.566612. bioRxiv. 2023. PMID: 37986907 Free PMC article. Preprint.
-
Looking beyond Self-Protection: The Eyes Instruct Systemic Immune Tolerance Early in Life.Brain Sci. 2023 Aug 30;13(9):1261. doi: 10.3390/brainsci13091261. Brain Sci. 2023. PMID: 37759864 Free PMC article.
-
Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles.Methods Mol Biol. 2023;2580:71-88. doi: 10.1007/978-1-0716-2740-2_4. Methods Mol Biol. 2023. PMID: 36374451
-
Identification of T cell antigens in the 21st century, as difficult as ever.Semin Immunol. 2022 Mar;60:101659. doi: 10.1016/j.smim.2022.101659. Epub 2022 Sep 29. Semin Immunol. 2022. PMID: 36183497 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources