Interstitial fibrosis in the heart: differences in extracellular matrix proteins and matrix metalloproteinases in end-stage dilated, ischaemic and valvular cardiomyopathy
- PMID: 16681691
- DOI: 10.1111/j.1365-2559.2006.02398.x
Interstitial fibrosis in the heart: differences in extracellular matrix proteins and matrix metalloproteinases in end-stage dilated, ischaemic and valvular cardiomyopathy
Abstract
Aims: To investigate whether or not there are differences in the distribution of extracellular matrix (ECM) proteins and matrix metalloproteinases (MMPs) in end-stage heart failure underlying different cardiomyopathies.
Methods and results: Thirty-nine explanted human hearts were investigated: 15 with dilated cardiomyopathy (DCM), 17 with ischaemic cardiomyopathy (ICM) and seven with valvular cardiomyopathy (VCM). Transmural samples from four different sites were investigated. Frozen sections were processed for immunohistochemistry for collagens type I, III, IV, laminin and fibronectin, as well as MMP-1, -2 and -9. Volume densities were determined. All ECM components were expressed more frequently in DCM than in ICM. Comparing ICM with VCM, all proteins were found more frequently in VCM than in ICM except for type III collagen, which was significantly more frequent in ICM. Comparing DCM and VCM, VCM showed significantly higher volume densities for type III collagen and laminin. MMPs showed only slight variations between the cardiomyopathies.
Conclusion: The distribution of ECM proteins differs between DCM, ICM and VCM, which suggests that they can be morphologically discriminated by interstitial fibrosis, especially by their expression of matrix proteins.
Similar articles
-
[Type IV collagenases (MMP-2 and MMP-9) and their substrates--intracellular proteins, hormones, cytokines, chemokines and their receptors].Postepy Biochem. 2007;53(1):37-45. Postepy Biochem. 2007. PMID: 17718386 Review. Polish.
-
Extracellular matrix proteins and matrix metalloproteinases differ between various right and left ventricular sites in end-stage cardiomyopathies.Virchows Arch. 2005 Apr;446(4):369-78. doi: 10.1007/s00428-004-1177-z. Epub 2005 Apr 2. Virchows Arch. 2005. PMID: 15806380
-
Immunoexpression of extracellular matrix proteins in human salivary gland development.Eur J Oral Sci. 2004 Dec;112(6):548-51. doi: 10.1111/j.1600-0722.2004.00169.x. Eur J Oral Sci. 2004. PMID: 15560840
-
Matrix metalloproteinases and their tissue inhibitors in the lesions of cardiac and pulmonary sarcoidosis: an immunohistochemical study.Hum Pathol. 2002 Dec;33(12):1158-64. doi: 10.1053/hupa.2002.129423. Hum Pathol. 2002. PMID: 12514782
-
[The extracellular matrix and cytoskeleton of the myocardium in cardiac inflammatory reaction].Herz. 1995 Apr;20(2):95-108. Herz. 1995. PMID: 7774871 Review. German.
Cited by
-
Multifunctional biomaterial platforms for blocking the fibrosis process and promoting cellular restoring effects in myocardial fibrosis therapy.Front Bioeng Biotechnol. 2022 Sep 15;10:988683. doi: 10.3389/fbioe.2022.988683. eCollection 2022. Front Bioeng Biotechnol. 2022. PMID: 36185428 Free PMC article.
-
Diffuse myocardial fibrosis: mechanisms, diagnosis and therapeutic approaches.Nat Rev Cardiol. 2021 Jul;18(7):479-498. doi: 10.1038/s41569-020-00504-1. Epub 2021 Feb 10. Nat Rev Cardiol. 2021. PMID: 33568808 Review.
-
Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy.Front Cell Dev Biol. 2021 Jan 12;8:624216. doi: 10.3389/fcell.2020.624216. eCollection 2020. Front Cell Dev Biol. 2021. PMID: 33511136 Free PMC article. Review.
-
Type III collagen (COL3A1): Gene and protein structure, tissue distribution, and associated diseases.Gene. 2019 Jul 30;707:151-171. doi: 10.1016/j.gene.2019.05.003. Epub 2019 May 7. Gene. 2019. PMID: 31075413 Free PMC article. Review.
-
Collagen biomaterial for the treatment of myocardial infarction: an update on cardiac tissue engineering and myocardial regeneration.Drug Deliv Transl Res. 2019 Oct;9(5):920-934. doi: 10.1007/s13346-019-00627-0. Drug Deliv Transl Res. 2019. PMID: 30877625 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical