Effects of visual experience on activity-dependent gene regulation in cortex
- PMID: 16582906
- DOI: 10.1038/nn1674
Effects of visual experience on activity-dependent gene regulation in cortex
Abstract
There are critical periods in development when sensory experience directs the maturation of synapses and circuits within neocortex. We report that the critical period in mouse visual cortex has a specific molecular logic of gene regulation. Four days of visual deprivation regulated one set of genes during the critical period, and different sets before or after. Dark rearing perturbed the regulation of these age-specific gene sets. In addition, a 'common gene set', comprised of target genes belonging to a mitogen-activated protein (MAP) kinase signaling pathway, was regulated by vision at all ages but was impervious to prior history of sensory experience. Together, our results demonstrate that vision has dual effects on gene regulation in visual cortex and that sensory experience is needed for the sequential acquisition of age-specific, but not common, gene sets. Thus, a dynamic interplay between experience and gene expression drives activity-dependent circuit maturation.
Similar articles
-
Extended plasticity of visual cortex in dark-reared animals may result from prolonged expression of cpg15-like genes.J Neurosci. 2002 Mar 1;22(5):1807-15. doi: 10.1523/JNEUROSCI.22-05-01807.2002. J Neurosci. 2002. PMID: 11880509 Free PMC article.
-
Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation.Nat Neurosci. 2010 Apr;13(4):450-7. doi: 10.1038/nn.2508. Epub 2010 Mar 14. Nat Neurosci. 2010. PMID: 20228806 Free PMC article.
-
Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity.Nat Neurosci. 2007 Dec;10(12):1569-77. doi: 10.1038/nn2008. Epub 2007 Nov 18. Nat Neurosci. 2007. PMID: 18026099
-
Nogo Receptor 1 Confines a Disinhibitory Microcircuit to the Critical Period in Visual Cortex.J Neurosci. 2016 Oct 26;36(43):11006-11012. doi: 10.1523/JNEUROSCI.0935-16.2016. J Neurosci. 2016. PMID: 27798181 Free PMC article.
-
miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity.Nat Neurosci. 2011 Sep 4;14(10):1240-2. doi: 10.1038/nn.2909. Nat Neurosci. 2011. PMID: 21892155 Free PMC article.
Cited by
-
Postsynaptic neuronal activity promotes regeneration of retinal axons.Cell Rep. 2023 May 30;42(5):112476. doi: 10.1016/j.celrep.2023.112476. Epub 2023 May 3. Cell Rep. 2023. PMID: 37141093 Free PMC article.
-
Level of Attention to Motherese Speech as an Early Marker of Autism Spectrum Disorder.JAMA Netw Open. 2023 Feb 1;6(2):e2255125. doi: 10.1001/jamanetworkopen.2022.55125. JAMA Netw Open. 2023. PMID: 36753277 Free PMC article.
-
Production of brain-derived neurotrophic factor gates plasticity in developing visual cortex.Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2214833120. doi: 10.1073/pnas.2214833120. Epub 2023 Jan 12. Proc Natl Acad Sci U S A. 2023. PMID: 36634145 Free PMC article.
-
Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors.Curr Biol. 2022 Nov 21;32(22):4783-4796.e3. doi: 10.1016/j.cub.2022.09.016. Epub 2022 Sep 29. Curr Biol. 2022. PMID: 36179691 Free PMC article.
-
Epigenetic and Transcriptional Regulation of Spontaneous and Sensory Activity Dependent Programs During Neuronal Circuit Development.Front Neural Circuits. 2022 May 18;16:911023. doi: 10.3389/fncir.2022.911023. eCollection 2022. Front Neural Circuits. 2022. PMID: 35664458 Free PMC article. Review.
Publication types
MeSH terms
Substances
Associated data
- Actions
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
