Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 May;6(3):203-14.
doi: 10.1007/s11882-006-0036-1.

Differential diagnosis of eosinophilic chronic rhinosinusitis

John C Sok, Berrylin J Ferguson
Review

Differential diagnosis of eosinophilic chronic rhinosinusitis

John C Sok et al. Curr Allergy Asthma Rep. 2006 May.

Abstract

Eosinophilic chronic rhinosinusitis (ECRS) encompasses a wide variety of etiologies. To date, a unifying pathophysiologic mechanism remains elusive. Eosinophilia is frequently, but not exclusively, caused by immunoglobulin (Ig)E-mediated hypersensitivity and is dominated by the associated cytokine milieu of Th2 inflammation. The provisional subcategories of ECRS include superantigen-induced eosinophilic chronic rhinosinusitis, allergic fungal sinusitis, nonallergic fungal eosinophilic chronic rhinosinusitis, and aspirin-exacerbated eosinophilic chronic rhinosinusitis. Within each subcategory, recent findings supporting distinct mechanisms that promote eosinophilic infiltration are presented, and, therefore, targeted therapeutic interventions with specific antibacterial, antifungal, or immune modulation may be indicated.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Allergy Clin Immunol. 2001 Oct;108(4):503-8 - PubMed
    1. JAMA. 1994 Feb 2;271(5):363-7 - PubMed
    1. Ann Allergy Asthma Immunol. 2001 Sep;87(3):181-8 - PubMed
    1. Chem Immunol. 2000;76:45-62 - PubMed
    1. Arch Otolaryngol Head Neck Surg. 1995 Dec;121(12):1396-402 - PubMed

LinkOut - more resources