Review
doi: 10.1016/j.devcel.2005.12.006.
Mechanisms of mechanotransduction
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- PMID: 16399074
- DOI: 10.1016/j.devcel.2005.12.006
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Review
Mechanisms of mechanotransduction
Dev Cell.
2006 Jan.
Free article
Erratum in
- Dev Cell. 2006 Mar;10(3):407
Abstract
Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces regulate a large array of physiological processes, and dysregulation of mechanical responses contributes to major human diseases. A survey of both specialized and widely expressed mechanosensitive systems suggests that physical forces provide a general means of altering protein conformation to generate signals. Specialized systems differ mainly in having acquired efficient mechanisms for transferring forces to the mechanotransducers.
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