Lymphvascular space involvement: an independent prognostic factor in endometrial cancer
- PMID: 15721428
- DOI: 10.1016/j.ygyno.2004.11.033
Lymphvascular space involvement: an independent prognostic factor in endometrial cancer
Abstract
Purpose of investigation: To evaluate whether lymphvascular space involvement (LVSI) is a risk factor for relapse of disease and lymph node metastasis in endometrial cancer.
Methods: From 1978 till 2003, 609 patients with epithelial endometrial cancer were treated at the Groningen University Medical Center. The association of LVSI and relapse of disease was evaluated in the total group of 609 patients and in a 'low' and 'high' risk stage I endometrial cancer group. In 239 surgically staged patients, the relation of LVSI and lymph node metastasis was investigated.
Results: The median age at diagnosis was 63 years (range 27-92 years) with a median follow-up of 58 months (range 0-236 months). More than half of the patients (56%) received adjuvant radiotherapy. LVSI was present in 123 patients (25,6%), and a prognostic factor for relapse of disease (multivariate analysis, P < 0.0001). In the 'low' and 'high' risk stage I endometrial cancer patients an increase of 2.6 times in relapse of disease was observed in the presence of LVSI. LVSI positive tumors were more likely to have metastasized to the pelvic lymph nodes (multivariate analysis, P = 0.001). In patients with proven negative nodes, LVSI was a prognostic factor for relapse of disease (univariate analysis, P = 0.02).
Conclusion: LVSI is a predictor of nodal disease and an independent prognostic factor for relapse of disease in all stages of endometrial cancer. Patients with stage I endometrial cancer with positive LVSI are at risk for relapse of disease and might therefore benefit from adjuvant therapy.
Content: The presence of lymphvascular space involvement (LVSI) in endometrial cancer is significantly and independently associated with an increased risk of pelvic lymph node metastases and/or relapse of disease.
Similar articles
-
Lymph-vascular space invasion and number of positive para-aortic node groups predict survival in node-positive patients with endometrial cancer.Gynecol Oncol. 2005 Mar;96(3):651-7. doi: 10.1016/j.ygyno.2004.11.026. Gynecol Oncol. 2005. PMID: 15721407
-
Lymphvascular space involvement compromises the survival of patients with stage I endometrial cancer: results of a multicenter study.Eur J Surg Oncol. 2007 Jun;33(5):644-7. doi: 10.1016/j.ejso.2007.01.009. Epub 2007 Feb 20. Eur J Surg Oncol. 2007. PMID: 17317084
-
[Survival, prognostic factors and modern tendencies in adjuvant treatment of diagnosed endometrial cancer patients with or without lymph node dissection].Akush Ginekol (Sofiia). 2009;48 Suppl 1:3-11. Akush Ginekol (Sofiia). 2009. PMID: 20387272 Bulgarian.
-
Stage IB endometrial cancer. Does lymphadenectomy replace adjuvant radiotherapy?Strahlenther Onkol. 2007 Nov;183(11):600-4. doi: 10.1007/s00066-007-1801-3. Strahlenther Onkol. 2007. PMID: 17960334 Review.
-
Is lymph vascular space involvement an independent prognostic factor in early cervical cancer?Gynecol Oncol. 2004 Feb;92(2):525-9. doi: 10.1016/j.ygyno.2003.11.020. Gynecol Oncol. 2004. PMID: 14766243 Review.
Cited by
-
Real-World Data Assessing the Impact of Lymphovascular Space Invasion on the Diagnostic Performance of Sentinel Lymph Node Mapping in Endometrial Cancer.Cancers (Basel). 2023 Dec 22;16(1):67. doi: 10.3390/cancers16010067. Cancers (Basel). 2023. PMID: 38201495 Free PMC article.
-
Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma.J Pers Med. 2023 Apr 25;13(5):723. doi: 10.3390/jpm13050723. J Pers Med. 2023. PMID: 37240893 Free PMC article.
-
Surgical restaging of patients with early‑stage endometrial cancer with lymphovascular invasion does not significantly impact their survival outcomes.Oncol Lett. 2023 Feb 8;25(3):122. doi: 10.3892/ol.2023.13708. eCollection 2023 Mar. Oncol Lett. 2023. PMID: 36844624 Free PMC article.
-
miR-149-3p Is a Potential Prognosis Biomarker and Correlated with Immune Infiltrates in Uterine Corpus Endometrial Carcinoma.Int J Endocrinol. 2022 Jun 8;2022:5006123. doi: 10.1155/2022/5006123. eCollection 2022. Int J Endocrinol. 2022. PMID: 35719192 Free PMC article.
-
Is Substantial Lymphovascular Space Invasion Prognostic for Clinical Outcomes in Type II Endometrial Cancer?Clin Oncol (R Coll Radiol). 2022 Jul;34(7):452-458. doi: 10.1016/j.clon.2022.02.018. Epub 2022 Mar 6. Clin Oncol (R Coll Radiol). 2022. PMID: 35264314 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Research Materials