Comparative analysis of breast cancer risk factors among African-American women and White women
- PMID: 15615914
- DOI: 10.1093/aje/kwh331
Comparative analysis of breast cancer risk factors among African-American women and White women
Abstract
The authors assessed risk factor profiles among 1,505 African-American and 1,809 White women in the 1993-2001 Carolina Breast Cancer Study. Multiple logistic regression models for case-control data were used to estimate odds ratios for several factors. Racial differences were observed in the prevalence of many breast cancer risk factors among both younger (aged 20-49 years) and older (aged 50-74 years) women. For older women, the magnitude and direction of associations were generally similar for African-American and White women, but important racial differences were observed among younger women. In particular, multiparity was associated with increased risk of breast cancer among younger African-American women (for three or four pregnancies: adjusted odds ratio (OR) = 1.5, 95% confidence interval (CI): 0.9, 2.6; for five or more pregnancies: OR = 1.4, 95% CI: 0.6, 3.1) but not among younger White women (for three or four pregnancies: OR = 0.7, 95% CI: 0.4, 1.2; for five or more pregnancies: OR = 0.8, 95% CI: 0.2, 3.0). The relations with age at first full-term pregnancy and nulliparity also varied by race. Case-only analyses before and after further adjustment for tumor stage and hormone receptor status revealed little effect on results. Hence, racial variations in both prevalences of and risks associated with particular factors may contribute to the higher incidence of breast cancer among younger African-American women.
Similar articles
-
Alcohol intake and invasive breast cancer risk by molecular subtype and race in the Carolina Breast Cancer Study.Cancer Causes Control. 2016 Feb;27(2):259-69. doi: 10.1007/s10552-015-0703-4. Epub 2015 Dec 24. Cancer Causes Control. 2016. PMID: 26705260 Free PMC article.
-
Race, Menopausal Hormone Therapy, and Invasive Breast Cancer in the Carolina Breast Cancer Study.J Womens Health (Larchmt). 2018 Mar;27(3):377-386. doi: 10.1089/jwh.2016.6063. Epub 2017 Jun 1. J Womens Health (Larchmt). 2018. PMID: 28570827 Free PMC article.
-
Reproductive factors and risk of breast carcinoma in a study of white and African-American women.Cancer. 2004 Jul 15;101(2):353-62. doi: 10.1002/cncr.20373. Cancer. 2004. PMID: 15241834
-
Ethnicity-related variation in breast cancer risk factors.Cancer. 2003 Jan 1;97(1 Suppl):222-9. doi: 10.1002/cncr.11014. Cancer. 2003. PMID: 12491485 Review.
-
Breast carcinoma etiology: current knowledge and new insights into the effects of reproductive and hormonal risk factors in black and white populations.Cancer. 2000 Mar 1;88(5 Suppl):1230-8. doi: 10.1002/(sici)1097-0142(20000301)88:5+<1230::aid-cncr9>3.0.co;2-f. Cancer. 2000. PMID: 10705360 Review.
Cited by
-
Dissecting the mediating and moderating effects of depression on the associations between traits and coronary artery disease: A two-step Mendelian randomization and phenome-wide interaction study.Int J Clin Health Psychol. 2023 Oct-Dec;23(4):100394. doi: 10.1016/j.ijchp.2023.100394. Epub 2023 Sep 5. Int J Clin Health Psychol. 2023. PMID: 37701760 Free PMC article.
-
Roles of Income and Acculturation in the Hispanic Paradox: Breastfeeding Among Hispanic Women.Matern Child Health J. 2023 Jun;27(6):1070-1080. doi: 10.1007/s10995-023-03643-2. Epub 2023 Mar 29. Matern Child Health J. 2023. PMID: 36988791
-
What Is Known about Breast Cancer in Young Women?Cancers (Basel). 2023 Mar 22;15(6):1917. doi: 10.3390/cancers15061917. Cancers (Basel). 2023. PMID: 36980802 Free PMC article. Review.
-
Patient Navigation Can Improve Breast Cancer Outcomes among African American Women in Chicago: Insights from a Modeling Study.J Urban Health. 2022 Oct;99(5):813-828. doi: 10.1007/s11524-022-00669-9. Epub 2022 Aug 8. J Urban Health. 2022. PMID: 35941401 Free PMC article.
-
Racial/ethnic differences in postmenopausal breast cancer risk by hormone receptor status: The multiethnic cohort study.Int J Cancer. 2022 Jan 15;150(2):221-231. doi: 10.1002/ijc.33795. Epub 2021 Sep 16. Int J Cancer. 2022. PMID: 34486728 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical