The Diabetes and Pre-eclampsia Intervention Trial
- PMID: 15464786
- DOI: 10.1016/j.ijgo.2004.06.015
The Diabetes and Pre-eclampsia Intervention Trial
Abstract
Objective: Rates of pre-eclampsia in women with type 1 diabetes are two to four times higher than in normal pregnancies. Diabetes is associated with antioxidant depletion and increased free radical production, and an increasing body of evidence suggests that oxidative stress and endothelial cell activation may be relevant to disease pathogenesis in pre-eclampsia. The Diabetes and Pre-eclampsia Intervention Trial (DAPIT) aims to establish if pregnant women with type 1 diabetes supplemented with vitamins C and E have lower rates of pre-eclampsia and endothelial activation compared with placebo treatment.
Methods: DAPIT is a randomised multicentre double-blind placebo-controlled trial that will recruit 756 pregnant women with type 1 diabetes from 20 metabolic-antenatal clinics in the UK over 4 years. Women are randomised to daily vitamin C (1000 mg) and vitamin E (400 IU) or placebo at 8-22 weeks of gestation until delivery. Maternal venous blood is obtained at randomisation, 26 and 34 weeks, for markers of endothelial activation and oxidative stress and to assess glycaemic control. The primary outcome of DAPIT is pre-eclampsia. Secondary outcomes include endothelial activation (PAI-1/PAI-2) and birthweight centile.
Similar articles
-
Vitamins C and E for prevention of pre-eclampsia in women with type 1 diabetes (DAPIT): a randomised placebo-controlled trial.Lancet. 2010 Jul 24;376(9737):259-66. doi: 10.1016/S0140-6736(10)60630-7. Epub 2010 Jun 26. Lancet. 2010. PMID: 20580423 Free PMC article. Clinical Trial.
-
Haptoglobin phenotype, pre-eclampsia, and response to supplementation with vitamins C and E in pregnant women with type-1 diabetes.BJOG. 2013 Sep;120(10):1192-9. doi: 10.1111/1471-0528.12288. Epub 2013 May 30. BJOG. 2013. PMID: 23718253 Free PMC article. Clinical Trial.
-
Aspirin in the prevention of pre-eclampsia in high-risk women: a randomised placebo-controlled PREDO Trial and a meta-analysis of randomised trials.BJOG. 2013 Jan;120(1):64-74. doi: 10.1111/j.1471-0528.2012.03493.x. Epub 2012 Nov 6. BJOG. 2013. PMID: 23126307 Review.
-
World Health Organisation multicentre randomised trial of supplementation with vitamins C and E among pregnant women at high risk for pre-eclampsia in populations of low nutritional status from developing countries.BJOG. 2009 May;116(6):780-8. doi: 10.1111/j.1471-0528.2009.02158.x. BJOG. 2009. PMID: 19432566 Clinical Trial.
-
Diabetes and the maternal resistance vasculature.Clin Sci (Lond). 2001 Dec;101(6):719-29. Clin Sci (Lond). 2001. PMID: 11724662 Review.
Cited by
-
Pre-Gestational Diabetes and Pregnancy Outcomes.Diabetes Ther. 2020 Dec;11(12):2873-2885. doi: 10.1007/s13300-020-00932-9. Epub 2020 Oct 3. Diabetes Ther. 2020. PMID: 33010001 Free PMC article.
-
Vitamin C supplementation in pregnancy.Cochrane Database Syst Rev. 2015 Sep 29;2015(9):CD004072. doi: 10.1002/14651858.CD004072.pub3. Cochrane Database Syst Rev. 2015. PMID: 26415762 Free PMC article. Review.
-
Vitamin E supplementation in pregnancy.Cochrane Database Syst Rev. 2015 Sep 7;2015(9):CD004069. doi: 10.1002/14651858.CD004069.pub3. Cochrane Database Syst Rev. 2015. PMID: 26343254 Free PMC article. Review.
-
Vitamins C and E: beneficial effects from a mechanistic perspective.Free Radic Biol Med. 2011 Sep 1;51(5):1000-13. doi: 10.1016/j.freeradbiomed.2011.05.017. Epub 2011 May 25. Free Radic Biol Med. 2011. PMID: 21664268 Free PMC article. Review.
-
Vitamins C and E for prevention of pre-eclampsia in women with type 1 diabetes (DAPIT): a randomised placebo-controlled trial.Lancet. 2010 Jul 24;376(9737):259-66. doi: 10.1016/S0140-6736(10)60630-7. Epub 2010 Jun 26. Lancet. 2010. PMID: 20580423 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical