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Comment
. 2004 Oct;53(10):1391-3.
doi: 10.1136/gut.2004.044990.

Food allergy in irritable bowel syndrome: new facts and old fallacies

E Isolauri  1 , S Rautava, M Kalliomäki
Affiliations
Comment

Food allergy in irritable bowel syndrome: new facts and old fallacies

E Isolauri et al. Gut. 2004 Oct.

Abstract

The notion of food allergy in irritable bowel syndrome (IBS) is not new. However, recent evidence suggests significant reduction in IBS symptom severity in patients on elimination diets, provided that dietary elimination is based on foods against which the individual had raised IgG antibodies. These findings should encourage studies dissecting the mechanisms responsible for IgG production against dietary antigens and their putative role in IBS

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Figure 1
Figure 1
An attempt to reformulate the original conception of the immunological basis of allergy. On exposure to dietary and microbial antigens, the naïve immune system matures either to establish appropriate immune reactivity and tolerance or, in the case of lack of suppressive and regulatory signals, develops inflammatory disease expressed as Th1 skewed autoimmune reactivity (for example, inflammatory bowel disease (IBD)) or Th2 skewed allergic disease. The exact nature of immune reactivity in irritable bowel syndrome (IBS) on this axis remains elusive.
See this image and copyright information in PMC

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