Modeling metastasis in vivo
- PMID: 15358632
- DOI: 10.1093/carcin/bgh261
Modeling metastasis in vivo
Abstract
Metastasis, the spread of a tumor from its primary site to other parts of the body, continues to be the most significant problem in the field of cancer. Patients who present with metastatic disease or those who develop metastases after successful management of the primary tumor carry a universally grave prognosis. To improve treatment outcomes for these patients a broader understanding of the biology of metastases is necessary. The biological complexity that characterizes metastasis requires complex experimental systems for its study. To a large extent the modeling of this biological complexity is only possible using animal models. The following review will summarize the strengths and weaknesses of available in vivo models of metastasis including transplantable syngeneic mouse and human-mouse xenografts, genetically engineered mice and naturally occurring cancers of companion animals (pet dogs and cats). No single metastasis model is sufficient to answer all questions. As such, the selection of the optimal model(s) for each biological or translational question is necessary.
Similar articles
-
Preclinical Modeling and Therapeutic Avenues for Cancer Metastasis to the Central Nervous System.Front Oncol. 2017 Sep 19;7:220. doi: 10.3389/fonc.2017.00220. eCollection 2017. Front Oncol. 2017. PMID: 28971065 Free PMC article. Review.
-
Development of Patient Derived Xenograft Models of Overt Spontaneous Breast Cancer Metastasis: A Cautionary Note.PLoS One. 2016 Jun 29;11(6):e0158034. doi: 10.1371/journal.pone.0158034. eCollection 2016. PLoS One. 2016. PMID: 27355476 Free PMC article.
-
Transplantable mouse tumor models of breast cancer metastasis.Methods Mol Biol. 2015;1267:367-80. doi: 10.1007/978-1-4939-2297-0_18. Methods Mol Biol. 2015. PMID: 25636479
-
The molecular biology of pulmonary metastasis.Thorac Surg Clin. 2006 May;16(2):115-24. doi: 10.1016/j.thorsurg.2005.12.003. Thorac Surg Clin. 2006. PMID: 16805200 Review.
-
Animal models of bone metastasis.Cancer. 2003 Feb 1;97(3 Suppl):748-57. doi: 10.1002/cncr.11150. Cancer. 2003. PMID: 12548572 Review.
Cited by
-
Distinct molecular profiles drive multifaceted characteristics of colorectal cancer metastatic seeds.J Exp Med. 2024 May 6;221(5):e20231359. doi: 10.1084/jem.20231359. Epub 2024 Mar 19. J Exp Med. 2024. PMID: 38502057
-
PIM Kinase Inhibition Attenuates the Malignant Progression of Metastatic Hepatoblastoma.Int J Mol Sci. 2023 Dec 28;25(1):427. doi: 10.3390/ijms25010427. Int J Mol Sci. 2023. PMID: 38203596 Free PMC article.
-
Sirtuin 5-mediated deacetylation of TAZ at K54 promotes melanoma development.Cell Oncol (Dordr). 2024 Jun;47(3):967-985. doi: 10.1007/s13402-023-00910-w. Epub 2023 Dec 19. Cell Oncol (Dordr). 2024. PMID: 38112979
-
Wild-type C-Raf gene dosage and dimerization drive prostate cancer metastasis.iScience. 2023 Nov 17;26(12):108480. doi: 10.1016/j.isci.2023.108480. eCollection 2023 Dec 15. iScience. 2023. PMID: 38089570 Free PMC article.
-
Carboxyl nanodiamonds inhibit melanoma tumor metastases by blocking cellular motility and invasiveness.PNAS Nexus. 2023 Nov 28;2(11):pgad359. doi: 10.1093/pnasnexus/pgad359. eCollection 2023 Nov. PNAS Nexus. 2023. PMID: 38034091 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous