Prenatal sonographic patterns in autosomal dominant polycystic kidney disease: a multicenter study
- PMID: 15229917
- DOI: 10.1002/uog.1098
Prenatal sonographic patterns in autosomal dominant polycystic kidney disease: a multicenter study
Abstract
Objective: To determine whether a specific prenatal sonographic pattern can be identified for autosomal dominant polycystic kidney disease (ADPKD) and if so whether it would be helpful in orienting complementary analysis, properly counseling parents and adapting pregnancy management.
Methods: A retrospective multicenter study was conducted in four prenatal diagnostic centers. The records of fetuses with a prenatal ultrasound examination revealing abnormal kidneys and with a final diagnosis of ADPKD were analyzed. Ultrasound analysis included: amount of amniotic fluid, bladder size, renal length, presence or absence of renal cysts and size of renal pelves, and was focused on parenchyma echogenicity and status of corticomedullary differentiation. Postnatal follow-up was reviewed.
Results: Of the 27 patients included in the study, 25 had hyperechogenic renal cortex and 20 had hypoechogenic medulla resulting in increased corticomedullary differentiation (CMD). In six cases, the medulla was hyperechogenic leading to absent or decreased CMD. One patient had normal cortical echogenicity and CMD. Renal cysts were present during the prenatal period in four patients (at 22 weeks in one case and after 30 weeks in three cases). In 12 patients, the cysts appeared after birth (within the first 6 months of postnatal life in 10 cases and by the age of 1 year in two cases). Elevated blood pressure was observed in only two cases and moderate chronic renal failure in one case.
Conclusion: We have described the sonographic presentation in fetuses with ADPKD: moderately enlarged hyperechogenic kidneys with increased CMD. Although not specific to ADPKD, these findings should prompt familial screening. Other prenatal sonographic features (absent or decreased CMD and cortical cysts) are less frequent.
Copyright 2004 ISUOG. Published by John Wiley & Sons, Ltd.
Similar articles
-
Prenatal ultrasonography of autosomal dominant polycystic kidney disease mimicking recessive type: case series.Pediatr Radiol. 2019 Jun;49(7):906-912. doi: 10.1007/s00247-018-4325-3. Epub 2019 Jan 10. Pediatr Radiol. 2019. PMID: 30631912
-
Imaging features of tuberous sclerosis complex with autosomal-dominant polycystic kidney disease: a contiguous gene syndrome.Pediatr Radiol. 2015 Mar;45(3):386-95. doi: 10.1007/s00247-014-3147-1. Epub 2014 Oct 30. Pediatr Radiol. 2015. PMID: 25355409
-
Hereditary polycystic kidney diseases in children: changing sonographic patterns through childhood.Pediatr Radiol. 2002 Mar;32(3):169-74. doi: 10.1007/s00247-001-0624-0. Pediatr Radiol. 2002. PMID: 12164348
-
Reproductive issues for adults with autosomal dominant polycystic kidney disease.Am J Kidney Dis. 2008 Feb;51(2):307-18. doi: 10.1053/j.ajkd.2007.09.010. Am J Kidney Dis. 2008. PMID: 18215709 Review.
-
Sonographic, clinical and genetic aspects of prenatal diagnosis of cystic kidney disease.Ultrasound Med Biol. 1991;17(7):687-94. doi: 10.1016/0301-5629(91)90100-b. Ultrasound Med Biol. 1991. PMID: 1781072 Review.
Cited by
-
Risk Severity Model for Pediatric Autosomal Dominant Polycystic Kidney Disease Using 3D Ultrasound Volumetry.Clin J Am Soc Nephrol. 2023 Feb 17;18(5):581-91. doi: 10.2215/CJN.0000000000000122. Online ahead of print. Clin J Am Soc Nephrol. 2023. PMID: 36800517 Free PMC article.
-
Prenatal ultrasonography of autosomal dominant polycystic kidney disease mimicking recessive type: case series.Pediatr Radiol. 2019 Jun;49(7):906-912. doi: 10.1007/s00247-018-4325-3. Epub 2019 Jan 10. Pediatr Radiol. 2019. PMID: 30631912
-
Is Autosomal Dominant Polycystic Kidney Disease Becoming a Pediatric Disorder?Front Pediatr. 2017 Dec 20;5:272. doi: 10.3389/fped.2017.00272. eCollection 2017. Front Pediatr. 2017. PMID: 29326910 Free PMC article. Review.
-
Clinicians' attitude towards family planning and timing of diagnosis in autosomal dominant polycystic kidney disease.PLoS One. 2017 Sep 29;12(9):e0185779. doi: 10.1371/journal.pone.0185779. eCollection 2017. PLoS One. 2017. PMID: 28961265 Free PMC article.
-
Fetal imaging prompts maternal diagnosis: autosomal dominant polycystic kidney disease.J Perinatol. 2015 Jul;35(7):537-8. doi: 10.1038/jp.2015.50. J Perinatol. 2015. PMID: 26111650
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical