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Review
. 2003 Jun;41(6):1183-90.
doi: 10.1161/01.HYP.0000069700.62727.C5. Epub 2003 Apr 21.

Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?

Richard J Johnson  1 , Duk-Hee Kang, Daniel Feig, Salah Kivlighn, John Kanellis, Susumu Watanabe, Katherine R Tuttle, Bernardo Rodriguez-Iturbe, Jaime Herrera-Acosta, Marilda Mazzali
Affiliations
Review

Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?

Richard J Johnson et al. Hypertension. 2003 Jun.

Abstract

Hyperuricemia is associated with hypertension, vascular disease, renal disease, and cardiovascular events. In this report, we review the epidemiologic evidence and potential mechanisms for this association. We also summarize experimental studies that demonstrate that uric acid is not inert but may have both beneficial functions (acting as an antioxidant) as well as detrimental actions (to stimulate vascular smooth muscle cell proliferation and induce endothelial dysfunction). A recently developed experimental model of mild hyperuricemia also provides the first provocative evidence that uric acid may have a pathogenic role in the development of hypertension, vascular disease, and renal disease. Thus, it is time to reevaluate the role of uric acid as a risk factor for cardiovascular disease and hypertension and to design human studies to address this controversy.

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