Role of antioxidant nutrients and lipid peroxidation in premature infants with respiratory distress syndrome and bronchopulmonary dysplasia
- PMID: 12660915
- DOI: 10.1055/s-2003-38315
Role of antioxidant nutrients and lipid peroxidation in premature infants with respiratory distress syndrome and bronchopulmonary dysplasia
Abstract
The objective of this study was to determine if newborn premature infants with severe respiratory distress syndrome (RDS) who developed bronchopulmonary dysplasia (BPD) demonstrate, within the first 3 days of life, lower blood levels of antioxidants and higher urine levels of lipid peroxidation products than premature infants who recovered from RDS. Perinatal variables (gestational age, birth weight, and Apgar scores) and antioxidant indices in cord and in third day of life plasma and red blood cell (RBC) samples from healthy premature infants (n = 35), infants with RDS (n = 23) and infants with BPD (n = 23) were examined. Antioxidant indices included selenium, alpha-tocopherol, total and oxidized glutathione, glutathione peroxidase, superoxide dismutase, and urinary malondialdehyde. By inferential statistics, only the perinatal variables and cord plasma selenium distinguished healthy premature infants from premature infants with RDS or BPD. From perinatal variables and antioxidant indices we calculated: (1) cord to third-day-of-life variable differences, (2) variable-to-variable ratios, and (3) ratios of a difference for one variable to a difference for any second variable. Subset regression analysis yielded an equation (adjusted R2 = 0.8839) that correctly predicted infants who developed BPD 100% of the time. Predictor variables for BPD were gestational age, Apgar at 1 min, cord and third-day-of-life RBC selenium, cord total glutathione, cord and third-day-of-life glutathione peroxidase and nine different ratios involving Apgar scores, RBC selenium, total and oxidized glutathione, alpha-tocopherol, glutathione peroxidase, and superoxide dismutase. In this study, there was no relationship between lipid peroxidation and BPD. There was a higher rate of patent ductus arteriosus, congestive heart failure, and retinopathy of prematurity in infants with BPD. This study confirms that low plasma selenium and alpha-tocopherol levels in premature infants (< or = 30 weeks' gestational age or lower) were significantly associated with an increased respiratory morbidity.
Similar articles
-
The relationship of selenium status to respiratory outcome in the very low birth weight infant.Pediatrics. 1995 Aug;96(2 Pt 1):314-9. Pediatrics. 1995. PMID: 7630691
-
Lymphocyte subpopulations in bronchopulmonary dysplasia.Am J Perinatol. 2003 Nov;20(8):465-75. doi: 10.1055/s-2003-45387. Am J Perinatol. 2003. PMID: 14703595 Clinical Trial.
-
Respiratory burst activity in bronchopulmonary dysplasia and changes with dexamethasone.Pediatr Pulmonol. 2003 May;35(5):392-9. doi: 10.1002/ppul.10279. Pediatr Pulmonol. 2003. PMID: 12687597 Clinical Trial.
-
[Bronchopulmonary dysplasia].Rev Mal Respir. 1996 Jul;13(3):243-9. Rev Mal Respir. 1996. PMID: 8765916 Review. French.
-
Populations at risk for developing respiratory syncytial virus and risk factors for respiratory syncytial virus severity: infants with predisposing conditions.Pediatr Infect Dis J. 2003 Feb;22(2 Suppl):S33-7; discussion S37-9. doi: 10.1097/01.inf.0000053883.08663.e5. Pediatr Infect Dis J. 2003. PMID: 12671450 Review.
Cited by
-
Oxygen Toxicity to the Immature Lung-Part II: The Unmet Clinical Need for Causal Therapy.Int J Mol Sci. 2021 Oct 2;22(19):10694. doi: 10.3390/ijms221910694. Int J Mol Sci. 2021. PMID: 34639034 Free PMC article. Review.
-
The Role of Nutrition in the Prevention and Management of Bronchopulmonary Dysplasia: A Literature Review and Clinical Approach.Int J Environ Res Public Health. 2021 Jun 9;18(12):6245. doi: 10.3390/ijerph18126245. Int J Environ Res Public Health. 2021. PMID: 34207732 Free PMC article. Review.
-
Neonatal Selenoenzyme Expression Is Variably Susceptible to Duration of Maternal Selenium Deficiency.Antioxidants (Basel). 2021 Feb 14;10(2):288. doi: 10.3390/antiox10020288. Antioxidants (Basel). 2021. PMID: 33672905 Free PMC article.
-
Hyperoxic Exposure Caused Lung Lipid Compositional Changes in Neonatal Mice.Metabolites. 2020 Aug 21;10(9):340. doi: 10.3390/metabo10090340. Metabolites. 2020. PMID: 32825609 Free PMC article.
-
Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia.Ital J Pediatr. 2019 Aug 24;45(1):112. doi: 10.1186/s13052-019-0676-0. Ital J Pediatr. 2019. PMID: 31445514 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical