Review
doi: 10.1515/JPM.2002.071.
Preterm premature rupture of the membranes and antioxidants: the free radical connection
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- PMID: 12530100
- DOI: 10.1515/JPM.2002.071
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Review
Preterm premature rupture of the membranes and antioxidants: the free radical connection
J Perinat Med.
2002.
Abstract
Aim: To discuss the role of oxidant stress in preterm, premature rupture of the membranes (PPROM).
Results: There is evidence to suggest that preterm, premature rupture of the membranes occurs secondary to focal collagen damage in the fetal membranes.
Conclusion: Oxidant stress caused by increased ROS formation and/or antioxidant depletion may disrupt collagen and cause premature membrane rupture. We propose that supplementation with vitamins C and E may synergistically protect the fetal membranes, and decrease the risks of PPROM.
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