The relation of the structure of progestational steroids to nucleolar differentiation in human endometrium
- PMID: 12256658
The relation of the structure of progestational steroids to nucleolar differentiation in human endometrium
Abstract
PIP: The relation of the structure of progestational steroids to nucleolar differentiation in human endometrium was studies by electron m icroscopy. Emdometrial biopsies were obtained from normal volunteers wi th regular menses and were cultured with the steroids to screen for nucl eolar basket formation. Progesterone, chlormadinone and medroxyprogeste rone induced the fine structural changes characteristic of postovulatory human endometrium when added to cultures of proliferative human endometrium. Progesterone, chlormadinone, medroxyprogesterone acetate, 19-norprogesterone and 19-norchlormadinone induced nucleolar differentiation, giant mitochondria and glycogen accumulation. Norethindrone, norethynodrel, dimethisterone, norgestrel and ethynodiol diacetate did not induce nuceolar differentiation but glycogen did accumulate and enlarged mitochondria were seen. These results suggest that the acyl group in the 17 beta position of the D ring of the progestational steroids is associated with nucleolar basket formation and that when this radicle is absent nucleolar differentiation does not occur and that glycogen accumulation and secretion of glycogen by the endometrial epithelial cell is a phenomenon separate from nucleolar differentiation.
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