Prognostic factors for malignant melanoma of the squamous mucosa of the head and neck
- PMID: 12131155
- DOI: 10.1097/00000478-200207000-00006
Prognostic factors for malignant melanoma of the squamous mucosa of the head and neck
Abstract
Primary malignant melanomas of the squamous mucosa of the head and neck are rare. To learn more about the prognostic significance of various histologic parameters we examined the pathologic features of squamous mucosa from 40 patients seen at a single institution and correlated them with clinical outcome. Follow-up information was available on 37 patients. Thirty-five were treated with surgical resection and two were treated with radiotherapy. Twenty-six were dead at follow-up. Twenty-one of them died of disease. The interval between diagnosis and death ranged from 1 month to 16.5 years (median survival, 2.4 years). Eleven patients were alive at 4 months to 19.5 years after the diagnosis: six of them with disease and five of them free of disease (mean follow-up, 3.5 years). Predictors of poor survival by univariate analysis were the presence of vascular invasion (overall survival, p = 0.007; disease-specific survival, p = 0.01), a polymorphous tumor cell population (overall survival, p = 0.007; disease-specific survival, p = 0.008), and necrosis (overall survival, p = 0.007; disease-specific survival, p = 0.056). However, because these three parameters were associated with each other, none of them remained of independent predictive value for outcome by multivariate analysis. No prognostic significance was found for tumor thickness, level of invasion, ulceration, mitotic index, or nerve/nerve sheath involvement. Thus, the histologic parameters relevant for the prognosis of squamous mucosa differ significantly from those of cutaneous melanomas.
Similar articles
-
Head and neck mucosal malignant melanoma: clinicopathologic correlation with contemporary review of prognostic indicators.Int J Surg Pathol. 2012 Feb;20(1):37-46. doi: 10.1177/1066896911417970. Epub 2011 Aug 23. Int J Surg Pathol. 2012. PMID: 21862490
-
Clinicopathologic differences in malignant melanoma arising in oral squamous and sinonasal respiratory mucosa of the upper aerodigestive tract.Arch Pathol Lab Med. 2003 Aug;127(8):997-1002. doi: 10.5858/2003-127-997-CDIMMA. Arch Pathol Lab Med. 2003. PMID: 12873174
-
Prognostic value of S100/CD31 and S100/podoplanin double immunostaining in mucosal malignant melanoma of the head and neck.Head Neck. 2015 Sep;37(9):1368-74. doi: 10.1002/hed.23761. Epub 2014 Jul 19. Head Neck. 2015. PMID: 24817089
-
Head and neck mucosal melanoma: clinicopathological analysis of 51 cases treated in a single cancer centre and review of the literature.Int J Oral Maxillofac Surg. 2016 Feb;45(2):135-40. doi: 10.1016/j.ijom.2015.08.987. Epub 2015 Dec 5. Int J Oral Maxillofac Surg. 2016. PMID: 26655030 Review.
-
Survival Outcomes of Mucosal Melanoma in the Head and Neck: Case Series and Review of Current Treatment Guidelines.J Oral Maxillofac Surg. 2016 Sep;74(9):1859-71. doi: 10.1016/j.joms.2016.03.008. Epub 2016 Mar 17. J Oral Maxillofac Surg. 2016. PMID: 27063590 Review.
Cited by
-
A Case Report of Oral Malignant Melanoma: A Silent Killer.Cureus. 2023 Mar 25;15(3):e36671. doi: 10.7759/cureus.36671. eCollection 2023 Mar. Cureus. 2023. PMID: 37102023 Free PMC article.
-
Primary mucosal melanomas of the head and neck are characterised by overexpression of the DNA mutating enzyme APOBEC3B.Histopathology. 2023 Mar;82(4):608-621. doi: 10.1111/his.14843. Epub 2022 Dec 5. Histopathology. 2023. PMID: 36416305 Free PMC article.
-
A review with an additional case: amelanotic malignant melanoma at mandibular gingiva.Int Cancer Conf J. 2020 Jul 18;9(4):175-181. doi: 10.1007/s13691-020-00425-3. eCollection 2020 Oct. Int Cancer Conf J. 2020. PMID: 32904143 Free PMC article. Review.
-
Primary retromolar malignant melanoma in a Latin American patient.J Int Med Res. 2020 Apr;48(4):300060520919245. doi: 10.1177/0300060520919245. J Int Med Res. 2020. PMID: 32326786 Free PMC article.
-
Sinonasal Melanoma: A Single Institutional Analysis and Future Directions.J Neurol Surg B Skull Base. 2019 Oct;80(5):484-492. doi: 10.1055/s-0038-1676355. Epub 2018 Dec 5. J Neurol Surg B Skull Base. 2019. PMID: 31534890 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical