The voltage-dependent anion channel: an essential player in apoptosis
- PMID: 12022949
- DOI: 10.1016/s0300-9084(02)01370-6
The voltage-dependent anion channel: an essential player in apoptosis
Abstract
The increase of outer mitochondrial membrane permeability is a central event in apoptotic cell death, since it releases several apoptogenic factors such as cytochrome c into the cytoplasm that activate the downstream destructive processes. The voltage-dependent anion channel (VDAC or mitochondrial porin) plays an essential role in the increase of mitochondrial membrane permeability, and it is regulated by the Bcl-2 family of proteins via direct interaction. Anti-apoptotic Bcl-2 family members close the VDAC, whereas some (but not all) pro-apoptotic members interact with the VDAC to generate a protein-conducting channel through which cytochrome c can pass. Although the VDAC is directly involved in the apoptotic increase of mitochondrial membrane permeability and is known to be a component of the permeability transition pore complex, its role in the regulation of outer membrane permeability can be separated from the occurrence of permeability transition events, such as mitochondrial swelling followed by rupture of the outer mitochondrial membrane. The VDAC not only interacts with Bcl-2 family members, but also with other proteins, and probably acts as a convergence point for a variety of life-or-death signals.
Similar articles
-
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC.Nature. 1999 Jun 3;399(6735):483-7. doi: 10.1038/20959. Nature. 1999. PMID: 10365962
-
Bcl-2 family of proteins: life-or-death switch in mitochondria.Biosci Rep. 2002 Feb;22(1):47-58. doi: 10.1023/a:1016061006256. Biosci Rep. 2002. PMID: 12418550 Review.
-
VDAC regulation by the Bcl-2 family of proteins.Cell Death Differ. 2000 Dec;7(12):1174-81. doi: 10.1038/sj.cdd.4400780. Cell Death Differ. 2000. PMID: 11175254 Review.
-
Bax and Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator.Oncogene. 2000 Sep 7;19(38):4309-18. doi: 10.1038/sj.onc.1203788. Oncogene. 2000. PMID: 10980606
-
Investigation of bax-induced release of cytochrome c from yeast mitochondria permeability of mitochondrial membranes, role of VDAC and ATP requirement.Eur J Biochem. 1999 Mar;260(3):684-91. doi: 10.1046/j.1432-1327.1999.00198.x. Eur J Biochem. 1999. PMID: 10102996
Cited by
-
Comparative- and network-based proteomic analysis of bacterial chondronecrosis with osteomyelitis lesions in broiler's proximal tibiae identifies new molecular signatures of lameness.Sci Rep. 2023 Apr 12;13(1):5947. doi: 10.1038/s41598-023-33060-y. Sci Rep. 2023. PMID: 37045932 Free PMC article.
-
Pro-Apoptotic and Anti-Cancer Activity of the Vernonanthura Nudiflora Hydroethanolic Extract.Cancers (Basel). 2023 Mar 6;15(5):1627. doi: 10.3390/cancers15051627. Cancers (Basel). 2023. PMID: 36900417 Free PMC article.
-
Appraisal of the Possible Role of PPARγ Upregulation by CLA of Probiotic Pediococcus pentosaceus GS4 in Colon Cancer Mitigation.PPAR Res. 2023 Feb 24;2023:9458308. doi: 10.1155/2023/9458308. eCollection 2023. PPAR Res. 2023. PMID: 36875279 Free PMC article.
-
Bioinformatic Analyses of Canonical Pathways of TSPOAP1 and its Roles in Human Diseases.Front Mol Biosci. 2021 Jun 15;8:667947. doi: 10.3389/fmolb.2021.667947. eCollection 2021. Front Mol Biosci. 2021. PMID: 34212002 Free PMC article.
-
Down regulation of lactate dehydrogenase initiates apoptosis in HeLa and MCF-7 cancer cells through increased voltage-dependent anion channel protein and inhibition of BCL2.Oncotarget. 2021 Apr 27;12(9):923-935. doi: 10.18632/oncotarget.27950. eCollection 2021 Apr 27. Oncotarget. 2021. PMID: 33953846 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
