Injection sclerotherapy for varicose veins
- PMID: 11869605
- DOI: 10.1002/14651858.CD001732
Injection sclerotherapy for varicose veins
Update in
-
Injection sclerotherapy for varicose veins.Cochrane Database Syst Rev. 2006 Oct 18;(4):CD001732. doi: 10.1002/14651858.CD001732.pub2. Cochrane Database Syst Rev. 2006. Update in: Cochrane Database Syst Rev. 2021 Dec 10;12:CD001732. doi: 10.1002/14651858.CD001732.pub3. PMID: 17054141 Updated. Review.
Abstract
Background: Injection sclerotherapy for varicose veins has been used widely since 1963, following popularisation of the technique by Fegan. The treatment aims to obliterate the lumen of varicose veins or thread veins, however, there is limited evidence regarding its efficacy.
Objectives: To determine whether sclerotherapy is effective in terms of symptomatic improvement and cosmetic appearance; has an acceptable complication rate; and to define rates of symptomatic or cosmetic varicose vein recurrence following sclerotherapy.
Search strategy: Publications describing randomised controlled trials (RCTs) of injection sclerotherapy for varicose veins (excluding comparisons with surgery) were sought through EMBASE and MEDLINE (from inception to March 2001) and hand-searching relevant journals, using the search strategy described by the Cochrane Peripheral Vascular Diseases Review Group. Bibliographies of papers identified were examined for further RCTs. Manufacturers of sclerosants were contacted for further trial information.
Selection criteria: RCTs of injection sclerotherapy versus graduated compression stockings or 'observation', or comparing different sclerosants, doses and post-compression bandaging techniques on patients with symptomatic and/or cosmetic varicose veins or thread veins were considered for inclusion in the review.
Data collection and analysis: Ten studies were included in the analysis. These compared: sodium tetradecyl sulphate (STD) versus an alternative sclerosant; sclerosant with or without local anaesthetic; application of Molefoam versus Sorbo pads to injection sites; elastic compression bandaging versus conventional bandaging; and short-term bandaging versus standard bandaging. Data were abstracted by both authors.
Main results: No RCTs compared sclerotherapy to graduated compression stockings or other non-surgical treatments. Two studies compared STD to alternative sclerosants and found no significant differences in outcome or complication rates. Adding local anaesthetic to sclerosant reduced the pain from injection (one study) but had no other effects. Comparison of Molefoam and Sorbo pad pressure dressings found no difference in outcome for erythema (redness) or successful sclerosis. The degree and duration of elastic compression had no significant effect on varicose vein recurrence rates, cosmetic appearance or symptomatic improvement. Increased compression prevented slipping of dressings but caused increased discomfort, as did increasing duration of compression.
Reviewer's conclusions: Evidence from RCTs suggests that type of sclerosant, local pressure dressing, degree and length of compression have no significant effect on the efficacy of sclerotherapy for varicose veins. This supports the current place of sclerotherapy in modern clinical practice, which is usually limited to treatment of recurrent varicose veins following surgery, and thread veins. A comparison of surgery versus sclerotherapy would be valuable.
Similar articles
-
Injection sclerotherapy for varicose veins.Cochrane Database Syst Rev. 2021 Dec 10;12(12):CD001732. doi: 10.1002/14651858.CD001732.pub3. Cochrane Database Syst Rev. 2021. PMID: 34883526 Free PMC article. Review.
-
Injection sclerotherapy for varicose veins.Cochrane Database Syst Rev. 2006 Oct 18;(4):CD001732. doi: 10.1002/14651858.CD001732.pub2. Cochrane Database Syst Rev. 2006. Update in: Cochrane Database Syst Rev. 2021 Dec 10;12:CD001732. doi: 10.1002/14651858.CD001732.pub3. PMID: 17054141 Updated. Review.
-
Graduated compression stockings for the initial treatment of varicose veins in people without venous ulceration.Cochrane Database Syst Rev. 2021 Jul 16;7(7):CD008819. doi: 10.1002/14651858.CD008819.pub4. Cochrane Database Syst Rev. 2021. PMID: 34271595 Free PMC article.
-
Endovenous ablation (radiofrequency and laser) and foam sclerotherapy versus conventional surgery for great saphenous vein varices.Cochrane Database Syst Rev. 2011 Oct 5;(10):CD005624. doi: 10.1002/14651858.CD005624.pub2. Cochrane Database Syst Rev. 2011. Update in: Cochrane Database Syst Rev. 2014 Jul 30;(7):CD005624. doi: 10.1002/14651858.CD005624.pub3. PMID: 21975750 Updated. Review.
-
Clinical effectiveness and cost-effectiveness of minimally invasive techniques to manage varicose veins: a systematic review and economic evaluation.Health Technol Assess. 2013 Oct;17(48):i-xvi, 1-141. doi: 10.3310/hta17480. Health Technol Assess. 2013. PMID: 24176098 Free PMC article. Review.
Cited by
-
Injection sclerotherapy for varicose veins.Cochrane Database Syst Rev. 2021 Dec 10;12(12):CD001732. doi: 10.1002/14651858.CD001732.pub3. Cochrane Database Syst Rev. 2021. PMID: 34883526 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials