Reduced cortical synaptic plasticity and GluR1 expression associated with fragile X mental retardation protein deficiency
- PMID: 11860268
- DOI: 10.1006/mcne.2001.1085
Reduced cortical synaptic plasticity and GluR1 expression associated with fragile X mental retardation protein deficiency
Abstract
Lack of expression of the fragile X mental retardation protein (FMRP), due to silencing of the FMR1 gene, causes the Fragile X syndrome. Although FMRP was characterized previously to be an RNA binding protein, little is known about its function or the mechanisms underlying the Fragile X syndrome. Here we report that the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit, GluR1, was decreased in the cortical synapses, but not in the hippocampus or cerebellum, of FMR1 gene knockout mice. Reduced long-term potentiation (LTP) was also found in the cortex but not in the hippocampus. Another RNA binding protein, FXR; the N-methyl-D-aspartate receptor subunit, NR2; and other learning-related proteins including c-fos, synapsin, myelin proteolipid protein, and cAMP response element binding protein were not different between FMR1 gene knockout and wild-type mice. These findings suggest that the depressed cortical GluR1 expression and LTP associated with FMRP deficiency could contribute to the Fragile X phenotype.
(C)2002 Elsevier Science (USA).
Similar articles
-
Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice.J Neurochem. 2009 Nov;111(3):635-46. doi: 10.1111/j.1471-4159.2009.06314.x. Epub 2009 Jul 30. J Neurochem. 2009. PMID: 19659572
-
Long-term potentiation in the hippocampus of fragile X knockout mice.Am J Med Genet. 1996 Aug 9;64(2):246-51. doi: 10.1002/(SICI)1096-8628(19960809)64:2<246::AID-AJMG2>3.0.CO;2-S. Am J Med Genet. 1996. PMID: 8844057
-
Age-dependent alterations of long-term synaptic plasticity in thyroid-deficient rats.Hippocampus. 2003;13(7):816-25. doi: 10.1002/hipo.10132. Hippocampus. 2003. PMID: 14620877
-
The fragile X syndrome: from molecular genetics to neurobiology.Ment Retard Dev Disabil Res Rev. 2004;10(1):60-7. doi: 10.1002/mrdd.20010. Ment Retard Dev Disabil Res Rev. 2004. PMID: 14994290 Review.
-
Differential translation and fragile X syndrome.Genes Brain Behav. 2005 Aug;4(6):360-84. doi: 10.1111/j.1601-183X.2005.00134.x. Genes Brain Behav. 2005. PMID: 16098135 Review.
Cited by
-
Impaired synaptic incorporation of AMPA receptors in a mouse model of fragile X syndrome.Front Mol Neurosci. 2023 Nov 9;16:1258615. doi: 10.3389/fnmol.2023.1258615. eCollection 2023. Front Mol Neurosci. 2023. PMID: 38025260 Free PMC article.
-
Neuroanatomical changes of ionotropic glutamatergic and GABAergic receptor densities in male mice modeling idiopathic and syndromic autism spectrum disorder.Front Psychiatry. 2023 Jul 21;14:1199097. doi: 10.3389/fpsyt.2023.1199097. eCollection 2023. Front Psychiatry. 2023. PMID: 37547211 Free PMC article.
-
Improvement of Learning and Memory by Elevating Brain D-Aspartate in a Mouse Model of Fragile X Syndrome.Mol Neurobiol. 2023 Nov;60(11):6410-6423. doi: 10.1007/s12035-023-03438-0. Epub 2023 Jul 15. Mol Neurobiol. 2023. PMID: 37453994 Free PMC article.
-
Progranulin is an FMRP target that influences macroorchidism but not behaviour in a mouse model of Fragile X Syndrome.Curr Res Neurobiol. 2023 Jun 16;5:100094. doi: 10.1016/j.crneur.2023.100094. eCollection 2023. Curr Res Neurobiol. 2023. PMID: 37416094 Free PMC article.
-
Axonal and presynaptic FMRP: Localization, signal, and functional implications.Hear Res. 2023 Mar 15;430:108720. doi: 10.1016/j.heares.2023.108720. Epub 2023 Feb 11. Hear Res. 2023. PMID: 36809742 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases