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Case Reports
. 2002 Feb;86(2):130-1.
doi: 10.1136/adc.86.2.130.

Acute ataxia complicating Langherans cell histiocytosis

A Polizzi  1 , S Coghill, M A McShane, W Squier
Affiliations
Case Reports

Acute ataxia complicating Langherans cell histiocytosis

A Polizzi et al. Arch Dis Child. 2002 Feb.

Abstract

A case is reported of a 3 year old boy with an acute history of cerebellar impairment and x ray evidence of apparent chest infection. At postmortem examination, his lungs but not the nervous system were found to be massively infiltrated by Langherans histiocytes. In retrospect, the acute ataxia was diagnosed as a paraneoplastic phenomenon secondary to Langherans cell histiocytosis (LCH). This represents a unique occurrence complicating LCH in childhood.

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Figures

Figure 1
Figure 1
Chest x ray picture showing widespread reticulonodular shadowing.
Figure 2
Figure 2
(A) Lung biopsy specimen from the child, showing a bronchiolocentric nodular lesion demarcated from the surrounding lung tissue. (B) Higher magnification of the same specimen, showing Langherans cells.
See this image and copyright information in PMC

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