Rationale and design for the SARIS trial; effect of statin on atherosclerosis and vascular remodeling assessed with intravascular sonography. Effect of Statin on Atherosclerosis and vascular Remodeling assessed with Intravascular Sonography
- PMID: 11800418
- DOI: 10.1023/a:1012762715944
Rationale and design for the SARIS trial; effect of statin on atherosclerosis and vascular remodeling assessed with intravascular sonography. Effect of Statin on Atherosclerosis and vascular Remodeling assessed with Intravascular Sonography
Abstract
Purpose: The SARIS study (effect of Statin on Atherosclerosis and vascular Remodeling assessed with Intravascular Sonography) is a prospective randomized multicenter trial designed to assess both morphological and functional cardiovascular effects of atorvastatin.
Methods: Participating centers will include 50 patients with normal to mildly elevated cholesterol levels eligible for balloon angioplasty and/or stent placement of the common iliac artery. Patients will be randomized to 1-year treatment with either low-dose (10 mg) or high-dose (80 mg) atorvastatin. The morphological effects of atorvastatin will be studied using intravascular ultrasound (IVUS); the effect of atorvastatin on both plaque volume and vascular remodeling seen at 1-year follow-up will be investigated. The functional cardiovascular effects of atorvastatin will be studied using dobutamine stress echocardiography (DSE); the effect of atorvastatin on myocardial coronary flow reserve at 6-months and 1-year follow-up will be investigated. The aims of the present study are noteworthy in respect that (1) IVUS is the only available technique to sensitively measure the effect of atorvastatin on both intimal hyperplasia and vascular remodeling, and (2) DSE is a non-invasive test to objectively quantify the effect of atorvastatin on the functionality of the coronary artery.
Similar articles
-
Effect of intensive atorvastatin therapy on coronary atherosclerosis progression, composition, arterial remodeling, and microvascular function.J Invasive Cardiol. 2012 Oct;24(10):522-9. J Invasive Cardiol. 2012. PMID: 23043036 Clinical Trial.
-
Impact of statins on progression of atherosclerosis: rationale and design of SATURN (Study of Coronary Atheroma by InTravascular Ultrasound: effect of Rosuvastatin versus AtorvastatiN).Curr Med Res Opin. 2011 Jun;27(6):1119-29. doi: 10.1185/03007995.2011.570746. Epub 2011 Mar 30. Curr Med Res Opin. 2011. PMID: 21446892 Clinical Trial.
-
Cumulative clinical trial data on atorvastatin for reducing cardiovascular events: the clinical impact of atorvastatin.Curr Med Res Opin. 2008 Apr;24(4):1217-29. doi: 10.1185/030079908x292001. Epub 2008 Mar 20. Curr Med Res Opin. 2008. PMID: 18358084 Review.
-
Use of intravascular ultrasound to compare effects of different strategies of lipid-lowering therapy on plaque volume and composition in patients with coronary artery disease.Circulation. 2001 Jul 24;104(4):387-92. doi: 10.1161/hc2901.093188. Circulation. 2001. PMID: 11468198 Clinical Trial.
-
Atorvastatin.Expert Opin Pharmacother. 2001 May;2(5):819-30. doi: 10.1517/14656566.2.5.819. Expert Opin Pharmacother. 2001. PMID: 11336625 Review.
Cited by
-
Perioperative statin therapy for improving outcomes during and after noncardiac vascular surgery.Cochrane Database Syst Rev. 2013 Jul 3;2013(7):CD009971. doi: 10.1002/14651858.CD009971.pub2. Cochrane Database Syst Rev. 2013. PMID: 23824754 Free PMC article. Review.
-
Statins and fibrates for preventing melanoma.Cochrane Database Syst Rev. 2005 Oct 19;2005(4):CD003697. doi: 10.1002/14651858.CD003697.pub2. Cochrane Database Syst Rev. 2005. PMID: 16235336 Free PMC article. Review.
-
Statin treatment and progression of atherosclerotic plaque burden.Drugs. 2003;63(9):893-911. doi: 10.2165/00003495-200363090-00004. Drugs. 2003. PMID: 12678574 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources