Reactive oxygen species and preterm premature rupture of membranes-a review
- PMID: 11312627
- DOI: 10.1053/plac.2001.0638
Reactive oxygen species and preterm premature rupture of membranes-a review
Abstract
Preterm premature rupture of membranes (PPROM) results initially from damage to collagen in the chorioamnion leading to a tear in the membrane. Tissue-damaging molecules called reactive oxygen species (ROS) are capable of damaging collagen in the chorioamnion that could lead to PPROM. This hypothesis is supported by epidemiological studies linking clinical conditions known to produce ROS or reduce antioxidant protection to PPROM, by in-vitro studies in which membrane segments exposed to ROS exhibited tissue alterations consistent with PPROM, and by clinical studies showing that chorioamnion and amniotic fluid samples obtained from PPROM patients exhibit excessive collagen degradation. The role of antioxidants to protect the chorioamnion from ROS damage has been demonstrated in one in-vitro study. A prospective, randomized blinded trial of antioxidant therapy during pregnancy is needed to evaluate this approach for the prevention of PPROM.
Copyright 2001 IFPA and Harcourt Publishers Ltd.
Similar articles
-
Vitamins C and E: missing links in preventing preterm premature rupture of membranes?Am J Obstet Gynecol. 2001 Jul;185(1):5-10. doi: 10.1067/mob.2001.115868. Am J Obstet Gynecol. 2001. PMID: 11483896 Review.
-
Pretreatment of human amnion-chorion with vitamins C and E prevents hypochlorous acid-induced damage.Am J Obstet Gynecol. 2000 Oct;183(4):979-85. doi: 10.1067/mob.2000.106676. Am J Obstet Gynecol. 2000. PMID: 11035350
-
Preterm premature rupture of the membranes and antioxidants: the free radical connection.J Perinat Med. 2002;30(6):447-57. doi: 10.1515/JPM.2002.071. J Perinat Med. 2002. PMID: 12530100 Review.
-
[Dietetic factors and premature rupture of fetal membranes. Effect of vitamin C on collagen degradation in the chorioamnion].Ginecol Obstet Mex. 1995 Apr;63:158-62. Ginecol Obstet Mex. 1995. PMID: 7768472 Spanish.
-
15-Hydroxyprostaglandin dehydrogenase protein expression in human fetal membranes with and without subclinical inflammation.Reprod Sci. 2007 Apr;14(3):260-9. doi: 10.1177/1933719107302433. Reprod Sci. 2007. PMID: 17636240
Cited by
-
Histologic Evidence of Epithelial-Mesenchymal Transition and Autophagy in Human Fetal Membranes.Am J Pathol. 2024 May;194(5):684-692. doi: 10.1016/j.ajpath.2023.12.011. Epub 2024 Feb 4. Am J Pathol. 2024. PMID: 38320630
-
The role of neutrophils in chorioamnionitis.Front Immunol. 2023 Jul 5;14:1198831. doi: 10.3389/fimmu.2023.1198831. eCollection 2023. Front Immunol. 2023. PMID: 37475854 Free PMC article. Review.
-
Maternal exposure to ambient air pollution mixture and premature rupture of membranes: Evidence from a large cohort in Southern California (2008-2018).Environ Int. 2023 Jul;177:108030. doi: 10.1016/j.envint.2023.108030. Epub 2023 Jun 11. Environ Int. 2023. PMID: 37329760 Free PMC article.
-
Antenatal and Postnatal Sequelae of Oxidative Stress in Preterm Infants: A Narrative Review Targeting Pathophysiological Mechanisms.Antioxidants (Basel). 2023 Feb 9;12(2):422. doi: 10.3390/antiox12020422. Antioxidants (Basel). 2023. PMID: 36829980 Free PMC article. Review.
-
Epithelial to mesenchymal transition (EMT) of feto-maternal reproductive tissues generates inflammation: a detrimental factor for preterm birth.BMB Rep. 2022 Aug;55(8):370-379. doi: 10.5483/BMBRep.2022.55.8.174. BMB Rep. 2022. PMID: 35880430 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources