Advanced glycation end-products: a review
- PMID: 11270668
- DOI: 10.1007/s001250051591
Advanced glycation end-products: a review
Erratum in
- Diabetologia 2002 Feb;45(2):293
Abstract
Advanced glycation end-products are a complex and heterogeneous group of compounds that have been implicated in diabetes related complications. At present it is not known if they are the cause or the consequence of the complications observed. We discuss the chemistry of advanced glycated end-product formation and their patho-biochemistry particularly in relation to the diabetic microvascular complications of retinopathy, neuropathy and nephropathy as well as their role in the accelerated vasculopathy observed in diabetes. The concept of carbonyl stress as a cause for advanced glycated end-product toxicity is mentioned. We discuss alterations in the concentrations of advanced glycated end-products in the body, particularly in relation to changes occurring with age, diabetes and its complications such as nephropathy. Problems relating to current methods of advanced glycated end-product detection and measurement are highlighted including the lack of a universally established method of detection or unit of measurement. Agents used for the treatment of advanced glycated end-product accumulation are reviewed, with an emphasis on the results of the recent phase III trials using aminoguanidine and diabetes related complications.
Similar articles
-
Receptor for advanced glycation end products (RAGE): a novel therapeutic target for diabetic vascular complication.Curr Pharm Des. 2008;14(5):487-95. doi: 10.2174/138161208783597416. Curr Pharm Des. 2008. PMID: 18289075 Review.
-
TAGE (toxic AGEs) theory in diabetic complications.Curr Mol Med. 2006 May;6(3):351-8. doi: 10.2174/156652406776894536. Curr Mol Med. 2006. PMID: 16712480 Review.
-
Advanced glycation end products (AGEs) and their receptor (RAGE) system in diabetic retinopathy.Curr Drug Discov Technol. 2006 Mar;3(1):83-8. doi: 10.2174/157016306776637555. Curr Drug Discov Technol. 2006. PMID: 16712466 Review.
-
Glycation and carboxymethyllysine levels in skin collagen predict the risk of future 10-year progression of diabetic retinopathy and nephropathy in the diabetes control and complications trial and epidemiology of diabetes interventions and complications participants with type 1 diabetes.Diabetes. 2005 Nov;54(11):3103-11. doi: 10.2337/diabetes.54.11.3103. Diabetes. 2005. PMID: 16249432 Free PMC article.
-
Advanced glycation end products and diabetic complications.Expert Opin Investig Drugs. 2002 Sep;11(9):1205-23. doi: 10.1517/13543784.11.9.1205. Expert Opin Investig Drugs. 2002. PMID: 12225243 Review.
Cited by
-
Bioarchitectural Design of Bioactive Biopolymers: Structure-Function Paradigm for Diabetic Wound Healing.Biomimetics (Basel). 2024 May 4;9(5):275. doi: 10.3390/biomimetics9050275. Biomimetics (Basel). 2024. PMID: 38786486 Free PMC article. Review.
-
An overview on glycation: molecular mechanisms, impact on proteins, pathogenesis, and inhibition.Biophys Rev. 2024 Apr 12;16(2):189-218. doi: 10.1007/s12551-024-01188-4. eCollection 2024 Apr. Biophys Rev. 2024. PMID: 38737201 Free PMC article. Review.
-
Inhibition and Mechanism of Protein Nonenzymatic Glycation by Lactobacillus fermentum.Foods. 2024 Apr 12;13(8):1183. doi: 10.3390/foods13081183. Foods. 2024. PMID: 38672858 Free PMC article.
-
Mesenchymal Stem Cells Regulate Microglial Polarization via Inhibition of the HMGB1/TLR4 Signaling Pathway in Diabetic Retinopathy.Inflammation. 2024 Apr 16. doi: 10.1007/s10753-024-02005-6. Online ahead of print. Inflammation. 2024. PMID: 38625640
-
Relationship Between Diabetes Mellitus and Periodontal/Peri-Implant Disease: A Contemporaneous Review.Int Dent J. 2024 Jun;74(3):426-445. doi: 10.1016/j.identj.2024.03.010. Epub 2024 Apr 12. Int Dent J. 2024. PMID: 38614881 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical