Serotonin in mania and in the mechanism of action of mood stabilizers: a review of clinical studies
- PMID: 11252655
- DOI: 10.1034/j.1399-5618.2000.020201.x
Serotonin in mania and in the mechanism of action of mood stabilizers: a review of clinical studies
Abstract
Objectives: Serotonin (5-hydroxytryptamine, 5-HT) was implicated in the pathophysiology of manic-depressive illness as early as 1958. Although extensive evidence has accumulated since then to support 5-HT's role in depression, relatively fewer studies examined its role in mania. The purpose of this paper was to review and summarize the current state of knowledge on the role of 5-HT in mania and its treatment.
Methods: We systemically reviewed clinical studies of 1) 5-HT function in mania and 2) 5-HT in the mechanism of action of mood stabilizers, including lithium and anticonvulsants.
Results: Review showed that cerebrospinal fluid, postmortem, platelet, neuroendocrine challenge, and tryptophan depletion studies provided some evidence to support the hypothesis that a 5-HT deficit is involved in mania and that enhancement of 5-HT neurotransmission exerts a mood-stabilizing effect.
Conclusions: There is some evidence from clinical studies for the contribution of 5-HT in mania and in the mechanism of action of mood stabilizers. However, it is very likely that other neurotransmitters also play important roles. Future directions for research include 1) in vivo study of 5-HT receptor subtypes using positron emission tomography, 2) investigation of the interaction between 5-HT and other neurotransmitter systems, and 3) determination of the relationships between diagnostic subtypes of mania and 5-HT function and other neurotransmitter systems.
Similar articles
-
Allopurinol for mania: a randomized trial of allopurinol versus placebo as add-on treatment to mood stabilizers and/or antipsychotic agents in manic patients with bipolar disorder.Bipolar Disord. 2014 Jun;16(4):441-7. doi: 10.1111/bdi.12202. Epub 2014 Apr 8. Bipolar Disord. 2014. PMID: 24712840 Clinical Trial.
-
Employing pharmacologic treatment of bipolar disorder to greatest effect.J Clin Psychiatry. 2004;65 Suppl 15:15-20. J Clin Psychiatry. 2004. PMID: 15554791 Review.
-
Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter.Clin Chem. 1994 Feb;40(2):288-95. Clin Chem. 1994. PMID: 7508830 Review.
-
[Quetiapin in bipolar disorders].Neuropsychopharmacol Hung. 2008 Dec;10(5):281-91. Neuropsychopharmacol Hung. 2008. PMID: 19419014 Review. Hungarian.
-
Glycogen Synthase Kinase-3β as a Putative Therapeutic Target for Bipolar Disorder.Curr Drug Metab. 2018;19(8):663-673. doi: 10.2174/1389200219666171227203737. Curr Drug Metab. 2018. PMID: 29283064 Review.
Cited by
-
Associations between dietary habits and bipolar disorder: a diet-wide mendelian randomization study.Front Psychiatry. 2024 May 10;15:1388316. doi: 10.3389/fpsyt.2024.1388316. eCollection 2024. Front Psychiatry. 2024. PMID: 38800064 Free PMC article.
-
A novel murine model of mania.Mol Psychiatry. 2023 Jul;28(7):3044-3054. doi: 10.1038/s41380-023-02037-8. Epub 2023 Mar 29. Mol Psychiatry. 2023. PMID: 36991130 Free PMC article.
-
Is SARS-CoV-2 a Risk Factor of Bipolar Disorder?-A Narrative Review.J Clin Med. 2022 Oct 14;11(20):6060. doi: 10.3390/jcm11206060. J Clin Med. 2022. PMID: 36294388 Free PMC article. Review.
-
Association between the loudness dependence of auditory evoked potentials and age in patients with schizophrenia and depression.J Int Med Res. 2022 Jul;50(7):3000605221109789. doi: 10.1177/03000605221109789. J Int Med Res. 2022. PMID: 35808808 Free PMC article.
-
Vortioxetine Induced Hypomania: A Case Presentation and Review of the Literature.Clin Psychopharmacol Neurosci. 2022 May 31;20(2):394-397. doi: 10.9758/cpn.2022.20.2.394. Clin Psychopharmacol Neurosci. 2022. PMID: 35466110 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical