Chicken soup inhibits neutrophil chemotaxis in vitro
- PMID: 11035691
- DOI: 10.1378/chest.118.4.1150
Chicken soup inhibits neutrophil chemotaxis in vitro
Abstract
Chicken soup has long been regarded as a remedy for symptomatic upper respiratory tract infections. As it is likely that the clinical similarity of the diverse infectious processes that can result in "colds" is due to a shared inflammatory response, an effect of chicken soup in mitigating inflammation could account for its attested benefits. To evaluate this, a traditional chicken soup was tested for its ability to inhibit neutrophil migration using the standard Boyden blindwell chemotaxis chamber assay with zymosan-activated serum and fMet-Leu-Phe as chemoattractants. Chicken soup significantly inhibited neutrophil migration and did so in a concentration-dependent manner. The activity was present in a nonparticulate component of the chicken soup. All of the vegetables present in the soup and the chicken individually had inhibitory activity, although only the chicken lacked cytotoxic activity. Interestingly, the complete soup also lacked cytotoxic activity. Commercial soups varied greatly in their inhibitory activity. The present study, therefore, suggests that chicken soup may contain a number of substances with beneficial medicinal activity. A mild anti-inflammatory effect could be one mechanism by which the soup could result in the mitigation of symptomatic upper respiratory tract infections.
Comment in
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Barbara, what's a nice girl like you doing writing an article like this? : the scientific basis of folk remedies for colds and flu.Chest. 2000 Oct;118(4):887-8. doi: 10.1378/chest.118.4.887. Chest. 2000. PMID: 11035648 Review. No abstract available.
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Chicken soup or Jewish medicine.Chest. 2001 Apr;119(4):1295. doi: 10.1378/chest.119.4.1295. Chest. 2001. PMID: 11296215 No abstract available.
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Free range chicken soup.Chest. 2001 Jun;119(6):1976. doi: 10.1378/chest.119.6.1976. Chest. 2001. PMID: 11399740 No abstract available.
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