Inadequate response to treatment in coronary heart disease : adverse effects of type D personality and younger age on 5-year prognosis and quality of life
- PMID: 10931802
- DOI: 10.1161/01.cir.102.6.630
Inadequate response to treatment in coronary heart disease : adverse effects of type D personality and younger age on 5-year prognosis and quality of life
Abstract
Background: Improvement in treatment of patients with coronary heart disease (CHD) has caused longer survival but also an increase in the number of patients at risk for subsequent cardiac events and impaired quality of life (QOL). We hypothesized that chronic emotional distress confers an increased risk of poor outcome despite appropriate treatment.
Methods and results: This prospective study examined the 5-year prognosis of 319 patients with CHD. Baseline assessment included symptoms of depression/anxiety and distressed personality type (type D-ie, high negative affectivity and social inhibition). The main end points were cardiac death or nonfatal myocardial infarction and impaired QOL. There were 22 cardiac events (16 nonfatal); they were related to left ventricular ejection fraction (LVEF) </=50%, poor exercise tolerance, age </=55 years, symptoms of depression, and type D personality. Multivariate analysis yielded LVEF </=50% (OR, 3.9; P=0.009), type D personality (OR, 8.9; P=0.0001), and age </=55 years (OR, 2.6; P=0.05) as independent predictors of cardiac events. Convergence of these risk factors predicted the absence of the expected therapeutic response that was observed in 10% of the patients. When 2 or 3 risk factors occurred together, the rate of poor outcome was 4-fold higher (P=0. 0001). Estimates of medical costs increased progressively with an increasing number of risk factors. Smoking, symptoms of depression, and type D personality were independent predictors of impaired QOL.
Conclusions: Decreased LVEF, type D personality, and younger age increase the risk of cardiac events; convergence of these factors predicts nonresponse to treatment. Emotionally stressed and younger patients with CHD represent high-risk groups deserving of special study.
Similar articles
-
Usefulness of type D personality in predicting five-year cardiac events above and beyond concurrent symptoms of stress in patients with coronary heart disease.Am J Cardiol. 2006 Apr 1;97(7):970-3. doi: 10.1016/j.amjcard.2005.10.035. Epub 2006 Feb 13. Am J Cardiol. 2006. PMID: 16563897
-
Personality, disease severity, and the risk of long-term cardiac events in patients with a decreased ejection fraction after myocardial infarction.Circulation. 1998 Jan 20;97(2):167-73. doi: 10.1161/01.cir.97.2.167. Circulation. 1998. PMID: 9445169
-
Personality as independent predictor of long-term mortality in patients with coronary heart disease.Lancet. 1996 Feb 17;347(8999):417-21. doi: 10.1016/s0140-6736(96)90007-0. Lancet. 1996. PMID: 8618481
-
Type D personality, cardiac events, and impaired quality of life: a review.Eur J Cardiovasc Prev Rehabil. 2003 Aug;10(4):241-8. doi: 10.1097/00149831-200308000-00005. Eur J Cardiovasc Prev Rehabil. 2003. PMID: 14555878 Review.
-
Type D Personality as a Risk Factor in Coronary Heart Disease: a Review of Current Evidence.Curr Cardiol Rep. 2018 Sep 12;20(11):104. doi: 10.1007/s11886-018-1048-x. Curr Cardiol Rep. 2018. PMID: 30209683 Free PMC article. Review.
Cited by
-
Revised Temperament and Character Inventory factors predict neuropsychiatric symptoms and aging-related cognitive decline across 25 years.Front Aging Neurosci. 2024 Feb 21;16:1335336. doi: 10.3389/fnagi.2024.1335336. eCollection 2024. Front Aging Neurosci. 2024. PMID: 38450380 Free PMC article.
-
Self-regulation of effort for a better health-related quality of life: a multidimensional activity pacing model for chronic pain and fatigue management.Ann Med. 2023;55(2):2270688. doi: 10.1080/07853890.2023.2270688. Epub 2023 Oct 23. Ann Med. 2023. PMID: 37871249 Free PMC article. Review.
-
Risk of recurrent cardiovascular events in coronary artery disease patients with Type D personality.Front Psychol. 2023 Mar 28;14:1119146. doi: 10.3389/fpsyg.2023.1119146. eCollection 2023. Front Psychol. 2023. PMID: 37057178 Free PMC article.
-
Distressed (Type D) personality is predicted by avoidance: evidence from a computer-based avatar task.PeerJ. 2022 Oct 27;10:e14302. doi: 10.7717/peerj.14302. eCollection 2022. PeerJ. 2022. PMID: 36320564 Free PMC article.
-
Type D Personality and Big Five Personality Traits and the Risk of Breast Cancer: A Case-Control Study.Front Psychiatry. 2022 Feb 22;13:723795. doi: 10.3389/fpsyt.2022.723795. eCollection 2022. Front Psychiatry. 2022. PMID: 35273526 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical