The influence of folic acid supplement on the outcome of pregnancies in the county of Funen in Denmark. Part II. Congenital anomalies. A randomised study
- PMID: 10597956
The influence of folic acid supplement on the outcome of pregnancies in the county of Funen in Denmark. Part II. Congenital anomalies. A randomised study
Abstract
Objective: The effect of folic acid supplement on the prevalence of congenital anomalies was studied in a Danish population.
Material and methods: From 1983 to 1986 all Danish women resident in the county of Funen were offered free folic acid when pregnant or planning a pregnancy. Folic acid dose was randomised to 2.5 or 1.0 mg. A randomised control group was not feasible for ethical reasons. Hospitals, midwives and most general practitioners cooperated to procure information on close to all pregnancies and congenital anomalies were recorded.
Results and conclusions: In a total of 14,021 pregnancies resulting in child birth 8184 women (58.4%) had folic acid with randomisation. Supplement was started in the randomised group before the last menstrual period in 1359/8184 (16.6%) and in the first 19 weeks of pregnancy in 6825/8184 (83.4%). The prevalence of congenital anomalies was 224 in 8293 children (27.0/1000). No dose-dependent differences were found in either total anomalies or in those specific malformations which have been reported to occur with reduced prevalence with periconceptional folic acid. The result was probably influenced by a start of supplement too late to affect malformation development in many cases and by the high level of both folic acid doses given compared to usual recommendations. Pregnancies without folic acid supplement showed prevalences similar to the supplemented groups.
Similar articles
-
The influence of folic acid supplement on the outcome of pregnancies in the county of Funen in Denmark. Part III. Congenital anomalies. An observational study.Eur J Obstet Gynecol Reprod Biol. 1999 Dec;87(2):115-8; discussion 103-4. Eur J Obstet Gynecol Reprod Biol. 1999. PMID: 10597957
-
The influence of folic acid supplement on the outcome of pregnancies in the county of Funen in Denmark. Part I.Eur J Obstet Gynecol Reprod Biol. 1999 Dec;87(2):105-10; discussion 103-4. Eur J Obstet Gynecol Reprod Biol. 1999. PMID: 10597955 Clinical Trial.
-
Prevention of NTDs with periconceptional multivitamin supplementation containing folic acid in China.Birth Defects Res A Clin Mol Teratol. 2008 Aug;82(8):592-6. doi: 10.1002/bdra.20471. Birth Defects Res A Clin Mol Teratol. 2008. PMID: 18634013
-
Evidence for suboptimal use of periconceptional folic acid supplements globally.BJOG. 2004 May;111(5):399-408. doi: 10.1111/j.1471-0528.2004.00115.x. BJOG. 2004. PMID: 15104602 Review.
-
[Folic acid and congenital malformation: scientific evidence and public health strategies].Ann Ig. 2008 Nov-Dec;20(6):519-30. Ann Ig. 2008. PMID: 19238877 Review. Italian.
Cited by
-
Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism.Cell Mol Life Sci. 2022 Jun 21;79(7):375. doi: 10.1007/s00018-022-04404-0. Cell Mol Life Sci. 2022. PMID: 35727412 Free PMC article.
-
Analysis OF C677T polymorphism in methylene tetrahydrofolate reductase (MTHFR) gene as a risk factor for congenital talipes equino varus (CTEV).J Clin Orthop Trauma. 2020 Nov 17;15:33-36. doi: 10.1016/j.jcot.2020.11.002. eCollection 2021 Apr. J Clin Orthop Trauma. 2020. PMID: 33717913 Free PMC article.
-
Vitamin supplementation for preventing miscarriage.Cochrane Database Syst Rev. 2016 May 6;2016(5):CD004073. doi: 10.1002/14651858.CD004073.pub4. Cochrane Database Syst Rev. 2016. PMID: 27150280 Free PMC article. Review.
-
Effects and safety of periconceptional oral folate supplementation for preventing birth defects.Cochrane Database Syst Rev. 2015 Dec 14;2015(12):CD007950. doi: 10.1002/14651858.CD007950.pub3. Cochrane Database Syst Rev. 2015. PMID: 26662928 Free PMC article. Review.
-
Preconception care: nutritional risks and interventions.Reprod Health. 2014 Sep 26;11 Suppl 3(Suppl 3):S3. doi: 10.1186/1742-4755-11-S3-S3. Epub 2014 Sep 26. Reprod Health. 2014. PMID: 25415364 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical