Dopamine D2 receptor-mediated regulation of partner preferences in female prairie voles (Microtus ochrogaster): a mechanism for pair bonding?
- PMID: 10443786
- DOI: 10.1037//0735-7044.113.3.602
Dopamine D2 receptor-mediated regulation of partner preferences in female prairie voles (Microtus ochrogaster): a mechanism for pair bonding?
Abstract
This study examined the role of dopamine (DA) in partner preference (PP) formation in female prairie voles (Microtus ochrogaster). The nonspecific DA antagonist haloperidol blocked mating-induced PP, whereas the nonspecific DA agonist apomorphine induced PP without mating. The D2 antagonist eticlopride, but not the D1 antagonist SCH23390, blocked PP, whereas the D2 agonist quinpirole, but not the D1 agonist SKF38393, induced PP without mating. Injections of eticlopride before or immediately after mating, but not 24 hr after mating, impaired PP, indicating that DA's effects were not due to an interference with mating or sensory recognition. Finally, intracerebroventricular injections of eticlopride diminished PP. Together, these data suggest that mating-induced PP requires activation of D2 receptors and that social experience may activate dopaminergic pathways, with enduring effects on behavior.
Similar articles
-
Neonatal exposure to the D1 agonist SKF38393 inhibits pair bonding in the adult prairie vole.Behav Pharmacol. 2011 Oct;22(7):703-10. doi: 10.1097/FBP.0b013e32834affd2. Behav Pharmacol. 2011. PMID: 21918384 Free PMC article.
-
D2 antagonist during development decreases anxiety and infanticidal behavior in adult female prairie voles (Microtus ochrogaster).Behav Brain Res. 2010 Jun 26;210(1):127-30. doi: 10.1016/j.bbr.2010.02.010. Epub 2010 Feb 10. Behav Brain Res. 2010. PMID: 20152865 Free PMC article.
-
Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds.Nat Neurosci. 2006 Jan;9(1):133-9. doi: 10.1038/nn1613. Epub 2005 Dec 4. Nat Neurosci. 2006. PMID: 16327783
-
A review of the discovery, pharmacological characterization, and behavioral effects of the dopamine D2-like receptor antagonist eticlopride.CNS Neurosci Ther. 2008 Fall;14(3):248-62. doi: 10.1111/j.1755-5949.2008.00047.x. CNS Neurosci Ther. 2008. PMID: 18801115 Free PMC article. Review.
-
Dopamine and sexual behavior.Neurosci Biobehav Rev. 1995 Spring;19(1):19-38. doi: 10.1016/0149-7634(94)00020-2. Neurosci Biobehav Rev. 1995. PMID: 7770195 Review.
Cited by
-
Nucleus accumbens dopamine release reflects the selective nature of pair bonds.Curr Biol. 2024 Feb 5;34(3):519-530.e5. doi: 10.1016/j.cub.2023.12.041. Epub 2024 Jan 12. Curr Biol. 2024. PMID: 38218185
-
Neuroendocrine mechanisms contributing to the coevolution of sociality and communication.Front Neuroendocrinol. 2023 Jul;70:101077. doi: 10.1016/j.yfrne.2023.101077. Epub 2023 May 20. Front Neuroendocrinol. 2023. PMID: 37217079 Free PMC article. Review.
-
Effects of a D2 receptor antagonist on repeated pair bond formation in the male prairie vole.Horm Behav. 2022 May;141:105149. doi: 10.1016/j.yhbeh.2022.105149. Epub 2022 Mar 3. Horm Behav. 2022. PMID: 35248868 Free PMC article.
-
Maternal dopamine encodes affective signals of human infants.Soc Cogn Affect Neurosci. 2022 May 5;17(5):503-509. doi: 10.1093/scan/nsab116. Soc Cogn Affect Neurosci. 2022. PMID: 34750627 Free PMC article.
-
Medial amygdala ERα expression influences monogamous behaviour of male prairie voles in the field.Proc Biol Sci. 2021 Aug 11;288(1956):20210318. doi: 10.1098/rspb.2021.0318. Epub 2021 Aug 4. Proc Biol Sci. 2021. PMID: 34344176 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous