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. 1999 Jun;103(11):1483-5.

doi: 10.1172/JCI7297.

Complexity in simplicity: monogenic disorders and complex cardiomyopathies

J Chen¹, K R Chien

Affiliations

Affiliation

¹ University of California-San Diego Salk NHLBI Program in Molecular Medicine, Department of Medicine and Center for Molecular Genetics, University of California-San Diego School of Medicine, La Jolla, California 92093, USA.

PMID: 10359556
PMCID: PMC408378
DOI: 10.1172/JCI7297

Complexity in simplicity: monogenic disorders and complex cardiomyopathies

J Chen et al. J Clin Invest. 1999 Jun.

. 1999 Jun;103(11):1483-5.

doi: 10.1172/JCI7297.

Authors

J Chen¹, K R Chien

Affiliation

¹ University of California-San Diego Salk NHLBI Program in Molecular Medicine, Department of Medicine and Center for Molecular Genetics, University of California-San Diego School of Medicine, La Jolla, California 92093, USA.

PMID: 10359556
PMCID: PMC408378
DOI: 10.1172/JCI7297

No abstract available

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Figures

Figure 1
The cytoskeletal protein network in cardomyocytes. To simplify the figure, only selective cytoskeletal proteins have been shown. “?” indicates that the location of the protein is uncertain. Mutations in genes that can cause HCM, DCM, and RCM are indicated by =, #, and *, respectively. Note that mutations in both α-cardiac actin (human) and δ-sarcoglycan (hamster) can result in either HCM or DCM.

See this image and copyright information in PMC

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