GTF2H4

GTF2H4
Estruturas disponíveis
PDB	Pesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB
	5IY9, 5IVW, 5IY7, 5IY8, 5IY6
Identificadores
Nomes alternativos	GTF2H4, Subunidade geral do fator de transcrição IIH 4
IDs externos	OMIM: 601760 HomoloGene: 7090 GeneCards: GTF2H4
Ontologia genética
Função molecular	• protein kinase activity; • ATP-dependent activity, acting on DNA; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0004003 DNA helicase activity; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • RNA polymerase II CTD heptapeptide repeat kinase activity; • double-stranded DNA binding; • ATPase activator activity; • GO:0000983 RNA polymerase II general transcription initiation factor activity;
Componente celular	• cariolinfa; • transcription factor TFIIH holo complex; • core TFIIH complex portion of holo TFIIH complex; • GO:0000441 transcription factor TFIIH core complex; • núcleo celular; • Fator de transcrição II D; • nuclear speck;
Processo biológico	• termination of RNA polymerase I transcription; • GO:0009373 regulation of transcription, DNA-templated; • phosphorylation of RNA polymerase II C-terminal domain; • transcription initiation from RNA polymerase I promoter; • transcription elongation from RNA polymerase II promoter; • 7-methylguanosine mRNA capping; • transcription by RNA polymerase II; • transcription, DNA-templated; • cellular response to DNA damage stimulus; • global genome nucleotide-excision repair; • transcription-coupled nucleotide-excision repair; • transcription initiation from RNA polymerase II promoter; • nucleotide-excision repair, DNA incision; • GO:0100026 reparo de ADN; • nucleotide-excision repair; • nucleotide-excision repair, preincision complex stabilization; • nucleotide-excision repair, preincision complex assembly; • nucleotide-excision repair, DNA incision, 5'-to lesion; • DNA duplex unwinding; • positive regulation of ATP-dependent activity; • nucleotide-excision repair, DNA duplex unwinding; • nucleotide-excision repair, DNA incision, 3'-to lesion; • GO:0001183 transcription elongation from RNA polymerase I promoter;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	Mais dados de referência de expressão
Ortólogos
	2968
	n/a
	ENSG00000213780
	n/a
	Q92759
	n/a
	NM_001517
	n/a
	NP_001508
	n/a
	Wikidata
Ver/Editar Humano

A subunidade geral do fator de transcrição IIH 4 é uma proteína que em humanos é codificada pelo gene GTF2H4.^[2]^[3]

Interações

GTF2H4 demonstrou interagir com: GTF2F1,^[4] MED21^[4] POLR2A,^[4] Proteína de ligação TATA,^[4] Fator de Transcrição II B^[4] e XPB.^[2]^[5]

Referências

↑ «Human PubMed Reference:»
↑ ^a ^b Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (abril de 1997). «Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH». EMBO J. 16 (5): 1093–102. PMC 1169708 . PMID 9118947. doi:10.1093/emboj/16.5.1093
↑ «Entrez Gene: GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa»
↑ ^a ^b ^c ^d ^e Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (maio de 1997). «BRCA1 is a component of the RNA polymerase II holoenzyme». Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. PMC 20825 . PMID 9159119. doi:10.1073/pnas.94.11.5605
↑ Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (julho de 2004). «A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A». Nat. Genet. 36 (7): 714–9. PMID 15220921. doi:10.1038/ng1387

Leitura adicional

Jeang KT (1998). «Tat, Tat-associated kinase, and transcription». J. Biomed. Sci. 5 (1): 24–7. PMID 9570510. doi:10.1007/BF02253352
Yankulov K, Bentley D (1998). «Transcriptional control: Tat cofactors and transcriptional elongation». Curr. Biol. 8 (13): R447-9. PMID 9651670. doi:10.1016/S0960-9822(98)70289-1
Maruyama K, Sugano S (1994). «Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides». Gene. 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8
Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D (1996). «Three functional classes of transcriptional activation domain». Mol. Cell. Biol. 16 (5): 2044–55. PMC 231191 . PMID 8628270
Drapkin R, Le Roy G, Cho H, Akoulitchev S, Reinberg D (1996). «Human cyclin-dependent kinase-activating kinase exists in three distinct complexes». Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6488–93. PMC 39050 . PMID 8692842. doi:10.1073/pnas.93.13.6488
Zhou Q, Sharp PA (1996). «Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat». Science. 274 (5287): 605–10. PMID 8849451. doi:10.1126/science.274.5287.605
Parada CA, Roeder RG (1996). «Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain». Nature. 384 (6607): 375–8. PMID 8934526. doi:10.1038/384375a0
García-Martínez LF, Ivanov D, Gaynor RB (1997). «Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes». J. Biol. Chem. 272 (11): 6951–8. PMID 9054383. doi:10.1074/jbc.272.11.6951
Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). «The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme». Mol. Cell. Biol. 17 (4): 1817–23. PMC 232028 . PMID 9121429
Rossignol M, Kolb-Cheynel I, Egly JM (1997). «Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH». EMBO J. 16 (7): 1628–37. PMC 1169767 . PMID 9130708. doi:10.1093/emboj/16.7.1628
Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (1997). «BRCA1 is a component of the RNA polymerase II holoenzyme». Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. PMC 20825 . PMID 9159119. doi:10.1073/pnas.94.11.5605
García-Martínez LF, Mavankal G, Neveu JM, Lane WS, Ivanov D, Gaynor RB (1997). «Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription». EMBO J. 16 (10): 2836–50. PMC 1169892 . PMID 9184228. doi:10.1093/emboj/16.10.2836
Nekhai S, Shukla RR, Kumar A (1997). «A human primary T-lymphocyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity». J. Virol. 71 (10): 7436–41. PMC 192089 . PMID 9311822
Cujec TP, Okamoto H, Fujinaga K, Meyer J, Chamberlin H, Morgan DO, Peterlin BM (1997). «The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II». Genes Dev. 11 (20): 2645–57. PMC 316603 . PMID 9334327. doi:10.1101/gad.11.20.2645
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). «Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library». Gene. 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3
Li XY, Green MR (1998). «The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor». Genes Dev. 12 (19): 2992–6. PMC 317190 . PMID 9765201. doi:10.1101/gad.12.19.2992
Ping YH, Rana TM (1999). «Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes». J. Biol. Chem. 274 (11): 7399–404. PMID 10066804. doi:10.1074/jbc.274.11.7399

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[1] «Human PubMed Reference:»

[pmid9118947-2] Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (abril de 1997). «Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH». EMBO J. 16 (5): 1093–102. PMC 1169708 . PMID 9118947. doi:10.1093/emboj/16.5.1093

[entrez-3] «Entrez Gene: GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa»

[pmid9159119-4] Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (maio de 1997). «BRCA1 is a component of the RNA polymerase II holoenzyme». Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. PMC 20825 . PMID 9159119. doi:10.1073/pnas.94.11.5605

[pmid15220921-5] Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (julho de 2004). «A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A». Nat. Genet. 36 (7): 714–9. PMID 15220921. doi:10.1038/ng1387

[2]