Thesis
The role of the lysine demethylases KDM5 and KDM6 in bone malignancies
- Abstract:
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Methylation of histone lysine residues functions as a dynamic, reversible mechanism for regulating gene expression and aberrations in this process have been linked with the development of cancer. Members of the lysine demethylase (KDM) family remove methyl marks from histones. KDM5B removes methyl marks from histone H3 lysine 4 (H3K4) whereas KDM6A and KDM6B remove methyl marks from histone H3 lysine 27 (H3K27).
In this thesis, GSK-J4, an inhibitor of KDM5B, KDM6A and KDM6B, is sho...
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Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Subjects:
- UUID:
-
uuid:b591861f-985b-4722-8027-492e750f3ff7
- Deposit date:
- 2017-06-29
Terms of use
- Copyright holder:
- Hookway, E
- Copyright date:
- 2016
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