Cardinals vs. Eagles predictions: NFL Week 5 picks as star QBs Jalen Hurts, Kyler Murray face off

Our NFL betting expert offers best betting picks and predictions for Sunday’s NFC matchup between the Philadelphia Eagles and Arizona Cardinals, scheduled to kick off at 4:25 p.m. ET on FOX.

The Eagles have run to the top of the NFC, using quarterback Jalen Hurts and running back Miles Sanders to bring balance to their offense with no signs of slowing down. The Cardinals (2-2) try their hand at denting Philadelphia’s perfect 4-0 mark.

Cardinals vs. Eagles predictions

• Jalen Hurts over 1.5 TD passes @ -125 with Caesars Sportsbook
• Miles Sanders over 78.5 yards from scrimmage @ -120 with Caesars Sportsbook
• Dallas Goedert over 3.5 receptions @ -127 with Caesars Sportsbook

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Cardinals vs. Eagles prediction and analysis

Arizona is more than capable of pulling the upset — thus, we’ll avoid the spread and money line bets here — but predicting which version of the Cardinals will show up at State Farm Stadium is the trick. They’ve alternated wins and losses and are 0-2 at home.

The Eagles are 4-0 and striving for a 5-0 start to the regular season for the first time since their 7-0 start led to a runner-up Super Bowl run under Andy Reid, Donovan McNabb and a hobbled Terrell Owens.

Jalen Hurts over 1.5 touchdown passes -125

Jalen Hurts’ MVP campaign continues to find legitimacy with 1,120 passing yards and four touchdown passes plus 205 yards and four more scores on the ground. In his only career game against the Cardinals, Hurts passed for 338 yards, 3 TDs and posted a 102.3 rating paired with 63 rushing yards and a TD. He’ll find easy opportunities against an Arizona defense allowing a 68.3 completion percentage and two TD passes per game.

Matchups favor Philadelphia across the board from pass protection to skill positions. Arizona’s comeback chops are credible, and the Eagles won’t have an opportunity to rest or shift into run-only mode.

Cardinals counterpart Kyler Murray leads the NFL through four games in pass completions (113) and attempts (173).

Our Pick: Jalen Hurts over 1.5 TD passes

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Miles Sanders over 78.5 total yards

Sanders had a breakout game last week, the second time in four games the Eagles went over 200 rushing yards. But Arizona’s run defense has been solid — 87 yards per game allowed — and will load up to take away the power game.

That suits Sanders well as an outside-in option with eight receptions this season. Christian McCaffrey had nine catches for 81 yards vs. Arizona last week.

He had 156 scrimmage yards (134 rush, 22 rec.) and two rushing TDs in Week 4. Sanders put up 90 yards from scrimmage (64 rush, 26 rec.) in his last outing against Arizona, and running backs have a 20-plus-yard reception in all four games vs. the Cardinals this season. McCaffrey had a 34-yarder last week.

Our Pick: Miles Sanders over 78.5 total yards

Dallas Goedert over 3.5 receptions

Across the field from former Eagles tight end Zach Ertz, Dallas Goedert is getting his day in the sun as Philadelphia’s primary underneath option. Arizona has a number of versatile defenders to flank Goedert, but most of that muscle is needed to contain No. 1 receiver AJ Brown and No. 2 option DeVonta Smith.

Goedert — 16 receptions for 240 yards this season — snagged five passes for 72 yards in Week 4 and has eight games with at least five receptions and 50 yards since the start of 2021, which is the fourth-best most among all tight ends.

Our Pick: Dallas Goedert over 3.5 receptions

Cardinals vs. Eagles odds

Team	Spread	Money Line	Total Points
Eagles	-5.0 (-110)	-235	Over 49.0 (-110)
Cardinals	+5.0 (-110)	+192	Under 49.0 (-110)