‘I worked with Marc at Nichols Institute Diagnostics in Wijchen with great pleasure. Marc was hired to implement Quality Assurance, ISO 9000 and GMT according to FDA regulations. Marc did a very good and professional job and “we” did get al the licenses to get our products on the US market in a very short time. I would recommend Marc, even after all these years, any time. Hopefully we meet again in the future.’
Sassenheim, Zuid-Holland, Nederland
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New publication reaffirming the long-term benefit of the ActiFIT Meniscal Scaffold for patients affected by the postmenisectomy syndrome. See:…
New publication reaffirming the long-term benefit of the ActiFIT Meniscal Scaffold for patients affected by the postmenisectomy syndrome. See:…
Gemarkeerd als interessant door Marc Klinkhamer
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Als je een 'Ik haat mijn baan'-dag hebt, probeer dan dit eens: Ga naar de apotheek, ga naar de thermometerafdeling en koop een rectale thermometer…
Als je een 'Ik haat mijn baan'-dag hebt, probeer dan dit eens: Ga naar de apotheek, ga naar de thermometerafdeling en koop een rectale thermometer…
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A leucine-to-proline mutation in the insulin receptor in a family with insulin resistance.
EMBO J. 1989 Sep;8(9):2503-7.
We have determined the primary structure of a mutant insulin receptor of a leprechaun patient born from a consanguineous marriage. A characteristic feature of leprechaunism is an extreme resistance to insulin. In this patient the insulin resistance seems to result from an observed lack of insulin binding to intact cells. Solubilization of cells in non-ionic detergents leads to the appearance of insulin receptors which can bind insulin. However, the insulin-stimulated autophosphorylation of the…
We have determined the primary structure of a mutant insulin receptor of a leprechaun patient born from a consanguineous marriage. A characteristic feature of leprechaunism is an extreme resistance to insulin. In this patient the insulin resistance seems to result from an observed lack of insulin binding to intact cells. Solubilization of cells in non-ionic detergents leads to the appearance of insulin receptors which can bind insulin. However, the insulin-stimulated autophosphorylation of the receptor's beta subunit is markedly reduced. Cloning and sequencing of cDNA derived from insulin receptor mRNA of this patient revealed a leucine-to-proline mutation at position 233 in the alpha subunit. By means of DNA amplification we found that the patient is homozygous for this mutation and that the parents and two grandparents from the consanguineous line are heterozygous. The heterozygous individuals all show decreased insulin binding to cultured fibroblasts. In addition, they are mildly insulin resistant in vivo. These observations show a linkage between the leucine-to-proline mutation and the observed insulin resistance in this family. We therefore conclude that the mutation in the homozygous form is responsible for the extreme insulin resistance in the leprechaun patient. The mutation for the first time characterizes a region in the insulin receptor which seems to be involved in transmitting the insulin binding signal to the tyrosine kinase domain.
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Word nu lid om dit te bekijkenMeer activiteiten van Marc
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Analysis of the #EPSCO meeting regarding #MDR extension and the #MDCG 2022-18 position paper bridging measure for the MDR #medtech #medicaldevices…
Analysis of the #EPSCO meeting regarding #MDR extension and the #MDCG 2022-18 position paper bridging measure for the MDR #medtech #medicaldevices…
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Nu het merendeel van de Corona patiënten op de IC ongevaccineerd blijken te zijn en de geplande zorg weer uitgesteld dreigt te worden krijg ik steeds…
Nu het merendeel van de Corona patiënten op de IC ongevaccineerd blijken te zijn en de geplande zorg weer uitgesteld dreigt te worden krijg ik steeds…
Gemarkeerd als interessant door Marc Klinkhamer
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please take a look at this very interesting webinar re. mechanical circulatory support during high risk PCI, using the PulseCath iVAC 2L
please take a look at this very interesting webinar re. mechanical circulatory support during high risk PCI, using the PulseCath iVAC 2L
Gedeeld door Marc Klinkhamer
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