Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Microsurgery in periodontics and oral implantology: a systematic review of current clinical applications and outcomes

Abstract

Objectives

The aim of this systematic review was to comprehensively explore the current trends and therapeutic approaches in which an operating microscope (OM) is used in periodontics and dental implant surgeries.

Materials and methods

A systematic search strategy was built to detect studies including various surgical techniques performed under an OM. PubMed, EMBASE, and SCOPUS databases were searched. No limitations in terms of time and language were applied. The data regarding the study design, type of procedure, treatment groups, and surgical outcomes were collected and analyzed descriptively. In addition, a bibliometric analysis was performed concerning the co-authorship and keyword co-occurrence network.

Results

Out of 1985 articles, finally, 55 met the inclusion criteria. Current periodontal and implant microsurgery trends consist of: periodontal therapy, dental implant microsurgery, soft tissue grafting and periodontal plastic surgery, bone augmentation, ridge preservation, and ortho-perio microsurgery. The bibliometric analysis revealed “guided tissue regeneration”, “periodontal regeneration” and “root coverage” being the most repeated keywords (landmark nodes). 132 authors within 29 clusters were identified, publishing within the frameworks of “periodontal and implant microsurgery”.

Conclusion

Within its limitations, this systematic review provides an overview of the latest trends in periodontal and implant microsurgery when considering the use of an OM as the magnification tool. Also, it discusses the reported success and outcomes of the mentioned procedures.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: PRISMA flow chart
Fig. 2: The results of the bibliometric analysis revealed 6 clusters and 76 keywords that appeared more than two times in the included studies.
Fig. 3: The keyword frequency analysis: this density graph depicts the keywords within the included studies.
Fig. 4: The visualization of the total of 132 authors, published in the field of “periodontal and implant microsurgery”.
Fig. 5: The basic periodontal and implant microsurgery instrument kit.
Fig. 6: Periodontal and dental implant microsurgical kit.
Fig. 7: Risk of bias assessment for included randomized controlled clinical trials.
Fig. 8: Risk of bias assessment for included non-randomized prospective controlled clinical studies.

Similar content being viewed by others

Data availability

The data is available upon request from the authors.

References

  1. Cortellini P, Tonetti MS. Microsurgical approach to periodontal regeneration. Initial evaluation in a case cohort. J Periodontol. 2001;72:559–69.

    Article  CAS  PubMed  Google Scholar 

  2. Yu SH, Oh TJ, Wang HL, Chan HL. Amnion-Chorion Membrane in Open-Wound Approach for Localized Horizontal Ridge Augmentation: A Case Series Report. Clin Adv Periodontics. 2022;12:101–5.

    Article  PubMed  Google Scholar 

  3. Srivastava R, Mohan R, Saravana Balaji MD, Vijay VK, Srinivasan S, Navarasu M. A Randomized Controlled Trial on a Minimally Invasive Microsurgical Versus Conventional Procedure for the Management of Localized Gingival Recession in Esthetic Zone using Alloderm. J Pharm Bioallied Sci. 2021;13:S476–83.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Di Gianfilippo R, Wang I, Steigmann L, Velasquez D, Wang H-L, Chan H-L. Efficacy of microsurgery and comparison to macrosurgery for gingival recession treatment: a systematic review with meta-analysis. Clin Oral Investig. 2021;25:4269–80.

    Article  PubMed  Google Scholar 

  5. Sultan N, Jafri Z, Sawai M, Bhardwaj A. Minimally invasive periodontal therapy. J Oral Biol Craniofacial Res. 2020;10:161–5.

    Article  Google Scholar 

  6. Sabri H, SamavatiJame F, Sarkarat F, Wang HL, Zadeh HH. Clinical efficacy of Vestibular Incision Subperiosteal Tunnel Access (VISTA) for treatment of multiple gingival recession defects: a systematic review, meta-analysis and meta-regression. Clin Oral Investig. 2023;27:7171–87.

    Article  PubMed  Google Scholar 

  7. Tamai S. History of microsurgery. Plast Reconstructive Surg. 2009;124:e282–94.

    Article  CAS  Google Scholar 

  8. Shanelec DA. Periodontal microsurgery. J Esthet Restor Dent. 2003;15:402–7. discussion 408.

    Article  PubMed  Google Scholar 

  9. Tibbetts LS, Shanelec D. Periodontal microsurgery. Dent Clin North Am. 1998;42:339–59.

    Article  CAS  PubMed  Google Scholar 

  10. Daniel RK. Microsurgery: through the looking glass. N. Engl J Med. 1979;300:1251–7.

    Article  CAS  PubMed  Google Scholar 

  11. Carr GB, Murgel CA. The use of the operating microscope in endodontics. Dent Clin. 2010;54:191–214.

    Google Scholar 

  12. Sitbon Y, Attathom T, St-Georges A. Minimal intervention dentistry II: part 1. Contribution of the operating microscope to dentistry. Br Dent J. 2014;216:125–30.

    Article  CAS  PubMed  Google Scholar 

  13. Shanelec DA, Tibbetts LS. A perspective on the future of periodontal microsurgery. Periodontology. 1996;11:58–64.

    Article  CAS  Google Scholar 

  14. Chambrone L, Pini Prato GP. Clinical insights about the evolution of root coverage procedures: The flap, the graft, and the surgery. J Periodontol. 2019;90:9–15.

    Article  PubMed  Google Scholar 

  15. Azaripour A, Kissinger M, Farina VSL, Van Noorden CJ, Gerhold‐Ay A, Willershausen B, et al. Root coverage with connective tissue graft associated with coronally advanced flap or tunnel technique: a randomized, double‐blind, mono‐centre clinical trial. J Clin Periodontol. 2016;43:1142–50.

    Article  PubMed  Google Scholar 

  16. Burkhardt R, Lang NP. Coverage of localized gingival recessions: comparison of micro‐and macrosurgical techniques. J Clin Periodontol. 2005;32:287–93.

    Article  PubMed  Google Scholar 

  17. Gargallo-Albiol J, Sinjab KH, Barootchi S, Chan H-L, Wang H-L. Microscope and micro-camera assessment of Schneiderian membrane perforation via transcrestal sinus floor elevation: A randomized ex vivo study. Clin Oral Implants Res. 2019;30:682–90.

    Article  PubMed  Google Scholar 

  18. Jiao Y, Hasegawa M, Inohara N. The role of oral pathobionts in dysbiosis during periodontitis development. J Dent Res. 2014;93:539–46.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol. 2015;15:30–44.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Cortellini P, Nieri M, Pini Prato G, Tonetti MS. Single minimally invasive surgical technique with an enamel matrix derivative to treat multiple adjacent intra‐bony defects: Clinical outcomes and patient morbidity. J Clin Periodontol. 2008;35:605–13.

    Article  PubMed  Google Scholar 

  21. Cortellini P, Tonetti MS. Improved wound stability with a modified minimally invasive surgical technique in the regenerative treatment of isolated interdental intrabony defects. J Clin Periodontol. 2009;36:157–63.

    Article  PubMed  Google Scholar 

  22. Cortellini P, Pini-Prato G, Nieri M, Tonetti MS. Minimally invasive surgical technique and enamel matrix derivative in intrabony defects: 2. Factors associated with healing outcomes. Int J Periodontics Restor Dent. 2009;29:257–65.

    Google Scholar 

  23. Bertossi D, Vercellotti T, Podesta A, Nocini PF. Orthodontic Microsurgery for Rapid Dental Repositioning in Dental Malpositions. J Oral Maxillofac Surg. 2011;69:747–53.

    Article  PubMed  Google Scholar 

  24. Cortellini P, Tonetti M, Prato GP. The partly epithelialized free gingival graft (pe-fgg) at lower incisors. A pilot study with implications for alignment of the mucogingival junction. J Clin Periodontol. 2012;39:674–80.

    Article  PubMed  Google Scholar 

  25. Penmetsa GS, Panda KD, Manthena AKR, Korukonda RR, Gadde P. Evaluating the efficacy of different magnification variables during root planing procedure under a surgical operating microscope in chronic periodontitis: A randomized clinical trial. J Indian Soc Periodontol. 2020;24:32–36.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Rodriguez JAM, Ruiz AJO. Apical approach in periodontal reconstructive surgery with enamel matrix derivate and enamel matrix derivate plus bone substitutes: a randomized, controlled clinical trial. Clin Oral Investig. 2022;26:2793–805.

    Article  Google Scholar 

  27. Shanelec DA, Tibbetts LS. Implant Microsurgery: Immediate Implant Placement With Implant‐Supported Provisional. Clin Adv Periodontics. 2011;1:161–72.

    Article  Google Scholar 

  28. Sabri H, Barootchi S, Heck T, Wang HL. Single‐rooted extraction socket classification: A systematic review and proposal of a new classification system based on morphologic and patient‐related factors. J Esthet Restor Dent. 2023;35:168–82.

  29. Pandolfi A. A modified approach to horizontal augmention of soft tissue around the implant: omega roll envelope flap. Description of surgical technique. La Clin Terapeutica. 2018;169:e165–9.

    CAS  Google Scholar 

  30. Jain D, Mohan R, Singh VD. Comparison of microsurgical and macrosurgical technique using bioactive synthetic bone graft and collagen membrane for an implant site development: A randomized controlled clinical trial. J Indian Soc Periodontol. 2019;23:448–460.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Sirinirund B, Chan H-L, Velasquez D. Microscope-Assisted Maxillary Sinus Augmentation: A Case Series. Int J Periodontics Restor Dent. 2021;41:531–7.

    Article  Google Scholar 

  32. Shakibaie- MB. Comparison of the effectiveness of two different bone substitute materials for socket preservation after tooth extraction: a controlled clinical study. Int J Periodontics Restor Dent. 2013;33:223–8.

    Article  Google Scholar 

  33. Shakibaie B. Microscope-controlled internal sinus floor elevation (MCI-SFE): A new technique to evaluate the sinus membrane during transcrestal lifting. Int J Microdentistry. 2013;4:12–19.

    Google Scholar 

  34. Shakibaie B, Sabri H, Blatz MB, Barootchi S. Comparison of the minimally-invasive roll-in envelope flap technique to the holding suture technique in implant surgery: A prospective case series. J Esthet Restor Dent. 2023;35:625–31.

    Article  PubMed  Google Scholar 

  35. Chambrone L, Tatakis DN. Periodontal soft tissue root coverage procedures: a systematic review from the AAP Regeneration Workshop. J Periodontol. 2015;86:S8–51.

    Article  PubMed  Google Scholar 

  36. Richardson CR, Allen EP, Chambrone L, et al. Periodontal Soft Tissue Root Coverage Procedures: Practical Applications From the AAP Regeneration Workshop. Clin Adv Periodontics. 2015;5:2–10.

    Article  PubMed  Google Scholar 

  37. Harris RJ. A comparison of two techniques for obtaining a connective tissue graft from the palate. Int J Periodontics Restor Dent. 1997;17:260–71.

    CAS  Google Scholar 

  38. Stefanini M, Barootchi S, Tavelli L, Marzadori M, Mazzotti C, Mounssif I, et al. Difficulty score for the treatment of isolated gingival recessions with the coronally advanced flap: a preliminary reliability study. Clin Oral Investig. 2022;27:559–69.

    Article  PubMed  Google Scholar 

  39. Zuhr O, Bäumer D, Hürzeler M. The addition of soft tissue replacement grafts in plastic periodontal and implant surgery: critical elements in design and execution. J Clin Periodontol. 2014;41:S123–42.

    Article  PubMed  Google Scholar 

  40. Gil Escalante M, Tatakis DN. Gingival cyst of the adult as early sequela of connective tissue grafting. Case Rep Dent. 2015;2015:473689.

  41. Maia VTG, Kahn S, Souza ABD, Fernandes G. De‐epithelialized connective tissue graft and the reminiscent epithelial content after harvested by the Harris’ technique: a histological and morphometrical case series. Clin Adv Periodontics. 2021;11:150–4.

  42. Kahn S, Araújo ITE, Dias AT, Balduíno A, Chambrone L, de Oliveira Fernandes GV. Histologic and histomorphometric analysis of connective tissue grafts harvested by the parallel incision method: a pilot randomized controlled trial comparing macro-and microsurgical approaches. Quintessence Int. 2021;52:772.

    PubMed  Google Scholar 

  43. Patel C, Mehta R, Joshi S, Hirani T, Joshi C. Comparative evaluation of treatment of localized gingival recessions with coronally advanced flap using microsurgical and conventional techniques. Contemp Clin Dent. 2018;9:613.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Francetti L, Del Fabbro M, Calace S, Testori T, Weinstein RL. Microsurgical treatment of gingival recession: a controlled clinical study. Int J Periodontics Restor Dent. 2005;25:181–8.

    Google Scholar 

  45. Francetti L, Del Fabbro M, Testori T, Weinstein RL. Periodontal microsurgery: report of 16 cases consecutively treated by the free rotated papilla autograft technique combined with the coronally advanced flap. Int J Periodontics Restor Dent. 2004;24:272–9.

    Google Scholar 

  46. Kahn S, WJdPR Rodrigues, MdO Barceleiro. Periodontal plastic microsurgery in the treatment of deep gingival recession after orthodontic movement. Case Rep. Dent. 2013;2013:851413.

    PubMed  PubMed Central  Google Scholar 

  47. Yadav D, Singh S, Roy S. Periodontal microsurgery for management of multiple marginal tissue recession using Zucchelli’s modification of coronally advanced flap and pericardium membrane in an esthetic zone. J Indian Soc Periodontol. 2019;23:284.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Kumar A, Bains VK, Jhingran R, Srivastava R, Madan R, Rizvi I. Patient-centered microsurgical management of gingival recession using coronally advanced flap with either platelet-rich fibrin or connective tissue graft: A comparative analysis. Contemp Clin Dent. 2017;8:293.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Thankkappan P, Roy S, Mandlik VB. Comparative evaluation of management of gingival recession using subepithelial connective tissue graft and collagen membrane by periodontal microsurgical technique: A clinical study of 40 cases. J Indian Soc Periodontol. 2016;20:189.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Agarwal SK, Jhingran R, Bains VK, Srivastava R, Madan R, Rizvi I. Patient-centered evaluation of microsurgical management of gingival recession using coronally advanced flap with platelet-rich fibrin or amnion membrane: A comparative analysis. Eur J Dent. 2016;10:121–33.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Kaval B, Renaud DE, Scott DA, Buduneli N. The role of smoking and gingival crevicular fluid markers on coronally advanced flap outcomes. J Periodontol. 2014;85:395–405.

    Article  CAS  PubMed  Google Scholar 

  52. Andrade PF, Grisi MF, Marcaccini AM, et al. Comparison between micro‐and macrosurgical techniques for the treatment of localized gingival recessions using coronally positioned flaps and enamel matrix derivative. J Periodontol. 2010;81:1572–9.

    Article  PubMed  Google Scholar 

  53. Nizam N, Bengisu O, Sönmez Ş. Micro- and Macrosurgical Techniques in the Coverage of Gingival Recession Using Connective Tissue Graft: 2 Years Follow-Up. J Esthet Restor Dent. 2015;27:71–83.

    Article  PubMed  Google Scholar 

  54. Kareem N, Mahendra J, Kumar KA. Triangular coronally advanced flap: Conventional versus Microsurgery. J Indian Soc Periodontol. 2018;22:73.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Bittencourt S, Del Peloso Ribeiro É, Sallum EA, Nociti FH Jr, Casati MZ. Surgical microscope may enhance root coverage with subepithelial connective tissue graft: A randomized‐controlled clinical trial. J Periodontol. 2012;83:721–30.

    Article  PubMed  Google Scholar 

  56. Pandey S, Mehta D. Treatment of localized gingival recession using the free rotated papilla autograft combined with coronally advanced flap by conventional (macrosurgery) and surgery under magnification (microsurgical) technique: A comparative clinical study. J Indian Soc Periodontol. 2013;17:765.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Chandra A, Gupta HL, Kumar P. Esthetic root coverage by sub epithelial connective tissue graft microsurgery: a case report.IJSS Case Reports & Reviews 2015;2:16–9.

  58. Jaiswal PG, Puri SS, Bhongade ML. Evaluation of effectiveness of subepithelial connective tissue graft in combination with coronally positioned flap in the treatment of isolated gingival recession in esthetic areas by using surgical microscope. J Datta Meghe Inst Med Sci Univ. 2017;12:79.

    Article  Google Scholar 

  59. Jindal U, Pandit N, Bali D, Malik R, Gugnani S. Comparative evaluation of recession coverage with sub-epithelial connective tissue graft using macrosurgical and microsurgical approaches: A randomized split mouth study. J Indian Soc Periodontol. 2015;19:203–7.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Mohan R, Jain R. Microsurgical Approach for Root Coverage of Receding Gingiva in the Esthetic Zone. Arch Reconstr Microsurg. 2013;22:69–73.

    Article  Google Scholar 

  61. Georgieva I. Coronally advanced flap technique for root coverage in the aesthetic zone of upper jaw. J IMAB Annu Proc Sci Pap. 2020;26:3267–70.

    Google Scholar 

  62. Dhir V, Jha A. Microsurgical treatment of gingival recession by subepithelial connective tissue graft: a case report. Med J Armed Forces India. 2011;67:293.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Nivetha R. Clinical outcome of coronally advanced flap and modified coronally advanced flap using microsurgery technique in the treatment of miller’s class I and II gingival recession: A Comparative study. Madurai: Best Dental Science College; 2018.

  64. Kahn S, de Oliveira LZ, Dias AT, Fernandes GVO. Clinical evaluation and biological understanding of the early step-by-step healing after periodontal microsurgery: A case report with PES analysis comparing initial and 31-day result. J Adv Periodontol Implant Dent. 2022;14:141–5.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Katariya C, Rajasekar A. Comparison between conventional and micro-assisted periodontal surgery: Case series. J Adv Pharm Technol Res. 2022;13:S348–52.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Karmakar S, Kamath DSG, Shetty NJ, Natarajan S. Treatment of Multiple Adjacent Class I and Class II Gingival Recessions by Modified Microsurgical Tunnel Technique and Modified Coronally Advanced Flap Using Connective Tissue Graft: A Randomized Mono-center Clinical Trial. J Int Soc Prev Community Dent. 2022;12:38–48.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Mohan R, Srivastava R, Gundappa M. Microsurgical Reconstruction of Receded Gingiva Using Alloderm In Esthetic Zone. Juniper Online J Orthopedic Orthoplastic Surg. 2017;1:30–2.

    Article  Google Scholar 

  68. Karring T, Östergaard E, Löe H. Conservation of tissue specifically after heterotopic transplantation of gingiva and alveolar mucosa. J Periodontal Res. 1971;6:282–93.

    Article  CAS  PubMed  Google Scholar 

  69. Induchoodan A, Remya R. Interdental Papilla Reconstruction using Modified Nordland’s Microsurgical Technique: A Case Study. Int J Drug Res Dent Sci. 2021;3:97–105.

    Google Scholar 

  70. Akiyama K. Papilla reconstruction using the dental operating microscope. Int. J. Microdentistry. 2009;1:25–9.

  71. Singh D, Jhingran R, Bains VK, Madan R, Srivastava R. Efficacy of platelet-rich fibrin in interdental papilla reconstruction as compared to connective tissue using microsurgical approach. Contemp Clin Dent. 2019;10:643.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Reddy SSP, Manohar B. Microsurgical approach for the management of gingival cleft: A case series and decision-making process. Clin Adv Periodontics. 2024. https://doi.org/10.1002/cap.10277.

  73. Mamoun J. Use of elevator instruments when luxating and extracting teeth in dentistry: clinical techniques. J Korean Assoc Oral Maxillofac Surg. 2017;43:204–11.

    Article  PubMed  PubMed Central  Google Scholar 

  74. Mamoun J. Use of high-magnification loupes or surgical operating microscope when performing prophylaxes, scaling or root planing procedures. N. Y State Dent J. 2013;79:48.

    PubMed  Google Scholar 

  75. Donthu N, Kumar S, Mukherjee D, Pandey N, Lim WM. How to conduct a bibliometric analysis: An overview and guidelines. J Bus Res. 2021;133:285–96.

    Article  Google Scholar 

  76. Sabri H, Wang HL, Peri-implantitis: A. bibliometric network analysis of top 100 most-cited research articles. Clin Implant Dent Relat Res. 2023;25:284–302.

    Article  PubMed  Google Scholar 

  77. Sabri H, Manouchehri N, Tavelli L, Kan JYK, Wang HL, Barootchi S. Five decades of research on immediate implant therapy: A modern bibliometric network analysis via Altmetric and level of evidence mapping. Clin Oral Implants Res. 2024. https://doi.org/10.1111/clr.14269.

  78. Ribeiro FV, Casarin RCV, Junior FHN, Sallum EA, Casati MZ. The Role of Enamel Matrix Derivative Protein in Minimally Invasive Surgery in Treating Intrabony Defects in Single-Rooted Teeth: A Randomized Clinical Trial. J Periodontol. 2011;82:522–32.

    Article  PubMed  Google Scholar 

  79. Ribeiro FV, Casarin RCV, Palma MAG, Junior FHN, Sallum EA, Casati RZ. Clinical and Patient-Centered Outcomes After Minimally Invasive Non-Surgical or Surgical Approaches for the Treatment of Intrabony Defects: A Randomized Clinical Trial. J Periodontol. 2011;82:1256–66.

    Article  PubMed  Google Scholar 

  80. Aslan S, Buduneli N, Cortellini P. Clinical outcomes of the entire papilla preservation technique with and without biomaterials in the treatment of isolated intrabony defects: A randomized controlled clinical trial. J Clin Periodontol. 2020;47:470–8.

    Article  CAS  PubMed  Google Scholar 

  81. Aslan S, Buduneli N, Cortellini P. Reconstructive surgical treatment of isolated deep intrabony defects with guided tissue regeneration using entire papilla preservation technique: A prospective case series. J Periodontol. 2021;92:488–95.

    Article  CAS  PubMed  Google Scholar 

  82. Sabri H, Sarkarat F, Mortezagholi B, Aghajani D. Non‐surgical management of oro‐antral communication using platelet‐rich fibrin: A review of the literature. Oral Surg. 2022;15:455–64.

    Article  Google Scholar 

  83. Cortellini P, Tonetti MS. Clinical and radiographic outcomes of the modified minimally invasive surgical technique with and without regenerative materials: a randomized-controlled trial in intra-bony defects. J Clin Periodontol. 2011;38:365–73.

    Article  PubMed  Google Scholar 

  84. Ahmad N, Tewari S, Narula SC, Sharma RK, Tanwar N. Platelet-rich fibrin along with a modified minimally invasive surgical technique for the treatment of intrabony defects: a randomized clinical trial. J Periodontal Implant Sci. 2019;49:355–65.

    Article  PubMed  PubMed Central  Google Scholar 

  85. Azar EL, Rojas MA, Mandalunis P, Gualtieri A, Carranza N. Histological evaluation of subepithelial connective tissue grafts harvested by two different techniques: Preliminary study in humans. Acta Odontol Latinoam. 2019;32:10–16.

    PubMed  Google Scholar 

  86. Rauten AM, Surlin P, Oprea B, Siloşi I, Moisa M, Caramizaru D, et al. Matrix metalloproteinase 9 levels in gingival crevicular fluid in patients after periodontal microsurgery for orthodontic induced gingival hypertrophy. Rom J Morphol Embryol. 2011;52:431–3.

    PubMed  Google Scholar 

Download references

Funding

The author(s) received no specific funding for this work.

Author information

Authors and Affiliations

Authors

Contributions

HS: Conceptualization, manuscript writing, data analysis, SA: Manuscript writing, data collection, final revision, PS: Manuscript writing, data collection, final revision, PD: Manuscript writing, data collection, final revision, PN: data collection, final revision, SHR: data collection, final revision, FS: Conceptualization, manuscript writing, critical review of final version.

Corresponding author

Correspondence to Hamoun Sabri.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sabri, H., Alhachache, S., Saxena, P. et al. Microsurgery in periodontics and oral implantology: a systematic review of current clinical applications and outcomes. Evid Based Dent (2024). https://doi.org/10.1038/s41432-024-01024-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1038/s41432-024-01024-4

Search

Quick links