Abstract
This study examined the effects of time restricted eating (TRE) on sex hormones in males and females, versus daily calorie restriction (CR). Adults with obesity (n = 90) were randomized to 1 of 3 groups for 12-months: 8-h TRE (eating only between 12:00 to 8:00 pm, with no calorie counting); CR (25% energy restriction daily); or control. Body weight decreased (P < 0.01) in the TRE and CR groups, relative to controls, in males, premenopausal females, and postmenopausal females, by month 12. Total testosterone, dehydroepiandrosterone (DHEA), and sex hormone binding globulin (SHBG) levels did not change over time, or between groups, in males, premenopausal females, and postmenopausal females. Estradiol, estrone, and progesterone were only measured in postmenopausal females, and remained unchanged. These findings suggest that TRE produces significant weight loss but does not impact circulating sex hormone levels in males and females with obesity over 12 months, relative to CR and controls.
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S.L. designed the research, conducted the clinical trial, and wrote the manuscript; S.C., M.E., V.P. and M-C.R. assisted with the conduction of the clinical trial; K.A.V. designed the research and wrote the manuscript. All authors have read and agreed to the published version of the manuscript.
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K.A.V. received author fees from Pan MacMillan for the book, The Fastest Diet. The other authors declare no conflicts of interest.
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Lin, S., Cienfuegos, S., Ezpeleta, M. et al. Effect of time restricted eating versus daily calorie restriction on sex hormones in males and females with obesity. Eur J Clin Nutr (2024). https://doi.org/10.1038/s41430-024-01461-5
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DOI: https://doi.org/10.1038/s41430-024-01461-5
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