Weiwei Yu
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About
Research
Publications
2022
The CD8α–PILRα interaction maintains CD8+ T cell quiescence
Zheng L, Han X, Yao S, Zhu Y, Klement J, Wu S, Ji L, Zhu G, Cheng X, Tobiasova Z, Yu W, Huang B, Vesely MD, Wang J, Zhang J, Quinlan E, Chen L. The CD8α–PILRα interaction maintains CD8+ T cell quiescence. Science 2022, 376: 996-1001. PMID: 35617401, DOI: 10.1126/science.aaz8658.Peer-Reviewed Original ResearchConceptsT cell quiescenceT cellsT cell pool sizeMaintenance of CD8Peripheral lymphoid organsCell quiescenceMemory CD8Antigen exposureLymphoid organsActivation phenotypeCD8Specific antigenCD8αInducible deletionCell pool sizeDiverse antigensAntigenMolecular mechanismsBroad repertoireExposureCellsQuiescent stateTumorsMicePILRα
2018
B7-H1 agonists could prevent disseminated inflammation by desensitizing cell susceptibility to cytotoxic T-cells
Yu W, Chen L, Guo S, Luo L, Chen L. B7-H1 agonists could prevent disseminated inflammation by desensitizing cell susceptibility to cytotoxic T-cells. OncoImmunology 2018, 7: e1504156. PMID: 30574431, PMCID: PMC6298416, DOI: 10.1080/2162402x.2018.1504156.Peer-Reviewed Original ResearchAllogeneic T cellsT cellsB7-H1Systemic inflammationPD-1B7-H1 monoclonal antibodyB7-H1/PDAllogeneic T-cell responsesB7-H1 mAbProgression of GVHDT cell responsesCo-inhibitory pathwaysT-cell lysisLong-term toleranceHost cell destructionNormal hematopoietic cellsDisseminated inflammationHost diseaseLeukemia responseAccelerated progressionMouse modelCell destructionInflammationMonoclonal antibodiesTypes of cellsB7-H1 maintains the polyclonal T cell response by protecting dendritic cells from cytotoxic T lymphocyte destruction
Chen L, Azuma T, Yu W, Zheng X, Luo L, Chen L. B7-H1 maintains the polyclonal T cell response by protecting dendritic cells from cytotoxic T lymphocyte destruction. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 3126-3131. PMID: 29507197, PMCID: PMC5866601, DOI: 10.1073/pnas.1722043115.Peer-Reviewed Original ResearchConceptsB7-H1 expressionDendritic cellsT cell responsesB7-H1CTL responsesTumor escapeB7-H1/PDCell responsesSubdominant T-cell responsesPolyclonal T cell responsesCombination cancer immunotherapyDifferent dendritic cellsAdaptive resistanceT lymphocyte destructionAdvanced human cancersMurine tumor modelsSurvival benefitTumor AgDominant AgAntibody blockadeCancer immunotherapyDC functionImmune destructionLymphocyte destructionT lymphocytes
2017
B7-DC (PD-L2) costimulation of CD4+ T-helper 1 response via RGMb
Nie X, Chen W, Zhu Y, Huang B, Yu W, Wu Z, Guo S, Zhu Y, Luo L, Wang S, Chen L. B7-DC (PD-L2) costimulation of CD4+ T-helper 1 response via RGMb. Cellular & Molecular Immunology 2017, 15: 888-897. PMID: 28479601, PMCID: PMC6207567, DOI: 10.1038/cmi.2017.17.Peer-Reviewed Original ResearchConceptsRepulsive guidance molecule bT cell responsesB7-DCPD-1T cellsB7-DC/PDCoinhibitory receptor PD-1T helper 1 responseTh2-mediated asthmaSmall airway inflammationReceptor PD-1T cell inhibitionExperimental mouse modelNaive mouse T cellsMouse T cellsAirway inflammationTh1 polarizationTh1 responseDendritic cellsLung pathologyMouse modelCostimulatory functionCostimulatory receptorsCD4Costimulation
2012
[Experimental study of inhibition of tumor cell proliferation by a novel gene SPATA12].
Liu Z, Lin Y, Liu X, Yu W, Zhang Y, Li D. [Experimental study of inhibition of tumor cell proliferation by a novel gene SPATA12]. Journal Of Central South University. Medical Sciences. 2012, 37: 222-7. PMID: 22561491, DOI: 10.3969/j.issn.1672-7347.2012.03.002.Peer-Reviewed Original ResearchConceptsTumor cell proliferationTesticular tumorsCell proliferationColony formationReverse transcription-polymerase chainSitu hybridization analysisTranscription-polymerase chainNormal adult testisDevelopment of tumorsDiphenyl tetrazolium bromideCell cycle genesTissue microarrayCyclin D1MRNA expressionTumor cellsInhibitory roleCyclin A1 geneCyclin E1RT-PCRTumorsDimethylthiazol-2MTT assayTetrazolium bromideCyclin B1Expression levels