About
Titles
Associate Research Scientist in Immunobiology
Education & Training
- PhD
- University of Washington (Seattle) (1996)
Research
Research at a Glance
Publications Timeline
A big-picture view of Gloria Zhu's research output by year.
10Publications
4,674Citations
Publications
2012
The B7-CD28 paradigm revisited--- a systemic receptor array approach (178.19)
Yao S, Zhu Y, Zhu G, Augustine M, Goode D, Wang J, Zheng L, Han X, Luo L, Broadwater M, Ruff W, Chen L. The B7-CD28 paradigm revisited--- a systemic receptor array approach (178.19). The Journal Of Immunology 2012, 188: 178.19-178.19. DOI: 10.4049/jimmunol.188.supp.178.19.Peer-Reviewed Original ResearchConceptsReceptor-ligand interactionsComplex receptor-ligand interactionsHuman transmembrane proteinsKinase-dependent pathwayCell cycle inhibitor p27Kip1High-throughput formatLow expression levelsTransmembrane proteinNon-overlapping domainsTarget proteinsB7-H2Bcl-xLB7-CD28 familyT cellsCell surfaceHematopoietic systemT cell activationExpression levelsHuman T cellsB7-1Potential targetSurvival factor Bcl-xLCD28 costimulationProteinCell activation
2002
Erratum: Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
Dong H, Strome S, Salomao D, Tamura H, Hirano F, Flies D, Roche P, Lu J, Zhu G, Tamada K, Lennon V, Celis E, Chen L. Erratum: Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion. Nature Medicine 2002, 8: 1039-1039. DOI: 10.1038/nm0902-1039c.Peer-Reviewed Original ResearchCitationsAltmetric
2001
Progressive Depletion of Peripheral B Lymphocytes in 4-1BB (CD137) Ligand/I-Eα-Transgenic Mice
Zhu G, Flies D, Tamada K, Sun Y, Rodriguez M, Fu Y, Chen L. Progressive Depletion of Peripheral B Lymphocytes in 4-1BB (CD137) Ligand/I-Eα-Transgenic Mice. The Journal Of Immunology 2001, 167: 2671-2676. PMID: 11509610, DOI: 10.4049/jimmunol.167.5.2671.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH Keywords4-1BB LigandAgingAnimalsAntibody FormationAntigen PresentationAntigens, CDBase SequenceB-LymphocytesDNA, ComplementaryHistocompatibility Antigens Class IIIn Vitro TechniquesLigandsLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicPhenotypePromoter Regions, GeneticReceptors, Nerve Growth FactorReceptors, Tumor Necrosis FactorSpleenT-LymphocytesTumor Necrosis Factor Receptor Superfamily, Member 9Tumor Necrosis Factor-alphaConceptsHumoral immune responseTransgenic miceT cellsImmune responseDefective humoral responseAllogeneic T cellsPeripheral B lymphocytesProgressive splenomegalyCTL responsesHumoral responseAg presentationB cellsB lymphocytesSelective depletionMiceCellsLow levelsProgressive depletionResponseSplenomegalySplenocytesLymphocytesIgGUnexpected functionRELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-κB
Sica G, Zhu G, Tamada K, Liu D, Ni J, Chen L. RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-κB. Blood 2001, 97: 2702-2707. PMID: 11313261, DOI: 10.1182/blood.v97.9.2702.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTumor necrosis factor receptorNecrosis factor receptorTumor necrosis factor receptor-associated factor 1Necrosis factor receptor-associated factor 1Factor receptorPresence of CD3T cell proliferationPeripheral blood leukocytesImmune cell proliferationTranscription factor NF-κBNF-kappaB pathwayFactor NF-κBLymph nodesLymphocyte reactionImmune responseBlood leukocytesNF-κBImmune systemLTbeta receptorTNFR superfamiliesHematologic tissuesCell proliferationFactor 1Hematopoietic tissuesReceptorsB7-H1 costimulation preferentially enhances CD28-independent T-helper cell function
Tamura H, Dong H, Zhu G, Sica G, Flies D, Tamada K, Chen L. B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood 2001, 97: 1809-1816. PMID: 11238124, DOI: 10.1182/blood.v97.6.1809.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAmino Acid SequenceAnimalsAntigens, CDB7-1 AntigenB7-2 AntigenB7-H1 AntigenBlood ProteinsCD28 AntigensCloning, MolecularCytokinesFemaleHumansInducible T-Cell Co-Stimulator LigandLigandsMembrane GlycoproteinsMiceMice, KnockoutMolecular Sequence DataPeptidesProteinsSequence AlignmentT-Lymphocytes, CytotoxicT-Lymphocytes, Helper-InducerConceptsT helper cell functionHuman B7-H1B7-H1T cell proliferationInducible costimulatorT cellsT-lymphocyte antigen-4Cytolytic T cell responsesT cell responsesCell functionGranulocyte-macrophage colony-stimulating factorP815 tumor cellsT cell growthColony-stimulating factorB7-like moleculeAllogeneic antigensLymphocyte responsesInterleukin-10Costimulatory pathwayAntigen-4IL-4Immunologic functionIL-2B7-1Cytokine secretionB7-H3: A costimulatory molecule for T cell activation and IFN-γ production
Chapoval A, Ni J, Lau J, Wilcox R, Flies D, Liu D, Dong H, Sica G, Zhu G, Tamada K, Chen L. B7-H3: A costimulatory molecule for T cell activation and IFN-γ production. Nature Immunology 2001, 2: 269-274. PMID: 11224528, DOI: 10.1038/85339.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAmino Acid SequenceAntigens, CDB7 AntigensB7-1 AntigenCells, CulturedCloning, MolecularCytokinesDendritic CellsHumansInterferon-gammaLymphocyte ActivationMolecular Sequence DataProtein IsoformsReceptors, ImmunologicSequence Homology, Amino AcidT-LymphocytesT-Lymphocytes, CytotoxicTranscription, GeneticTumor Cells, CulturedConceptsIFN-γ productionDendritic cellsB7-H3 proteinT cellsPhorbol myristate acetateB7-H3Inducible costimulatorT-lymphocyte antigen-4Cell-mediated immune responsesPeripheral blood mononuclear cellsAllogeneic T cellsBlood mononuclear cellsInterferon-γ ProductionB7 homolog 3Cytotoxic T cellsB7-H3 mRNAB7 family membersActivated T cellsT cell activationT cell receptor signalingPD-1Cell receptor signalingCostimulatory pathwayInflammatory cytokinesAntigen-4
2000
Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS
Wang S, Zhu G, Chapoval A, Dong H, Tamada K, Ni J, Chen L. Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood 2000, 96: 2808-2813. PMID: 11023515, DOI: 10.1182/blood.v96.8.2808.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAbataceptAmino Acid SequenceAnimalsAntigens, CDAntigens, DifferentiationAntigens, Differentiation, T-LymphocyteCarrier ProteinsCD3 ComplexCell DivisionCHO CellsCloning, MolecularCricetinaeCricetulusCTLA-4 AntigenDendritic CellsDNA, ComplementaryGenes, ImmunoglobulinHumansImmunoconjugatesImmunoglobulin GInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinInterleukin-10Interleukin-2LigandsLymphocyte ActivationMiceMice, Inbred BALB CMolecular Sequence DataProtein Structure, TertiaryProteinsRecombinant Fusion ProteinsSequence AlignmentSequence Homology, Amino AcidT-LymphocytesTransfectionConceptsB7-H2T cellsMonocyte-derived immature dendritic cellsImmature dendritic cellsIL-10 productionSecretion of interleukinT cell proliferationB7-like moleculeT cell moleculesImmunoglobulin fusion proteinDendritic cellsCell surface expressionCD3 ligationSurface expressionChinese hamster ovary cellsCostimulationHamster ovary cellsCellsOvary cellsPutative ligandCTLA4IgInterleukinCD3Fusion proteinICOSModulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway
Tamada K, Shimozaki K, Chapoval A, Zhu G, Sica G, Flies D, Boone T, Hsu H, Fu Y, Nagata S, Ni J, Chen L. Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nature Medicine 2000, 6: 283-289. PMID: 10700230, DOI: 10.1038/73136.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAmino Acid SequenceAnimalsCD18 AntigensCell LineCloning, MolecularGraft vs Host DiseaseGranulocyte-Macrophage Colony-Stimulating FactorHumansImmunity, CellularInterferon-gammaMembrane ProteinsMiceModels, BiologicalMolecular Sequence DataRecombinant Fusion ProteinsRecombinant ProteinsReverse Transcriptase Polymerase Chain ReactionSequence AlignmentSequence Homology, Amino AcidT-LymphocytesTransfectionTumor Cells, CulturedTumor Necrosis Factor Ligand Superfamily Member 14Tumor Necrosis Factor-alphaConceptsCo-stimulatory pathwaysTumor necrosis factorT cell-mediated immunityCytolytic T cell responsesT-cell co-stimulatory pathwaysBlockade of LIGHTCell-mediated immunityT cell responsesHost disease modelGranulocyte-macrophage colony-stimulating factorPotential therapeutic targetCo-stimulatory activityT cell growthColony-stimulating factorHost diseaseTherapeutic immunityP815 tumorImmunoregulatory functionsNecrosis factorGamma interferonSoluble receptorTherapeutic targetDisease modelsImmunityGraftImmunoglobulin Fusion Proteins as a Tool for Evaluation of T-Cell Costimulatory Molecules
Chapoval A, Zhu G, Chen L. Immunoglobulin Fusion Proteins as a Tool for Evaluation of T-Cell Costimulatory Molecules. Methods In Molecular Medicine 2000, 45: 247-255. PMID: 21341062, DOI: 10.1385/1-59259-079-9:247.Peer-Reviewed Original ResearchCitationsConceptsCostimulatory moleculesT cell receptorT cell costimulatory moleculesWeak tumor antigensT lymphocyte activationPeptide-major histocompatibility complexImmunoglobulin fusion proteinPoor immunogenicityLack of expressionImmune responseTumor antigensAccessory signalsImmune systemHistocompatibility complexRecent studiesFusion proteinImmunogenicityAntigenReceptors
1999
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nature Medicine 1999, 5: 1365-1369. PMID: 10581077, DOI: 10.1038/70932.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCell-mediated immune responsesB7-H1B7 familyImmune responseT-cell co-stimulatory pathwaysAntigen-specific humoralInterleukin-10 secretionT cell responsesCo-stimulatory moleculesCo-stimulatory pathwaysT cell proliferationAllogeneic antigensInterleukin-10Polyclonal stimuliB7-1Interleukin-2CD28Negative regulationHumoralResponseICOSAntigenSecretion
Links & Media
News
Get In Touch
Contacts
Email