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Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice
Accumulation of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau is a histopathological hallmark of Alzheimer’s disease (AD) and...
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Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in TauP301L-BiFC mice
Tau oligomers play critical roles in tau pathology and are responsible for neuronal cell death and transmitting the disease in the brain....
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Tau Protein Methods and Protocols
This volume explores the latest advancements and techniques to study Tau protein that include basic and advanced methods and protocols from in vitro...
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CSF p-tau205: a biomarker of tau pathology in Alzheimer’s disease
Post-mortem staging of Alzheimer’s disease (AD) neurofibrillary pathology is commonly performed by immunohistochemistry using AT8 antibody for...
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Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer’s disease
Insoluble pathogenic proteins accumulate along blood vessels in conditions of cerebral amyloid angiopathy (CAA), exerting a toxic effect on vascular...
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Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice
TMEM106B , a gene encoding a lysosome membrane protein, is tightly associated with brain aging, hypomyelinating leukodystrophy, and multiple...
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TDP-43 pathology is associated with increased tau burdens and seeding
BackgroundMost Alzheimer’s Disease (AD) cases also exhibit limbic predominant age-related TDP-43 encephalopathy neuropathological changes (LATE-NC),...
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LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression
BackgroundMutations in leucine-rich repeat kinase 2 ( LRRK2 ) are the most common cause of familial Parkinson’s disease (PD). These mutations elevate...
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Tau pathology is associated with synaptic density and longitudinal synaptic loss in Alzheimer’s disease
The associations of synaptic loss with amyloid-β (Aβ) and tau pathology measured by positron emission tomography (PET) and plasma analysis in...
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Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer’s disease: implications for biomarker development and therapeutic targeting
Tauopathies are neurodegenerative diseases that typically require postmortem examination for a definitive diagnosis. Detecting neurotoxic tau...
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Accurate digital quantification of tau pathology in progressive supranuclear palsy
The development of novel treatments for Progressive Supranuclear Palsy (PSP) is hindered by a knowledge gap of the impact of neurodegenerative...
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Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice
The cholinesterase inhibitor donepezil is used to improve Aβ pathology and cognitive function in patients with Alzheimer’s disease (AD). However, the...
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The Spectrum of Tau Pathology in Human Prion Disease
Intracellular deposition of hyperphosphorylated tau characterizes tauopathies: there is a spectrum from neuron-predominant through mixed neuronal and...
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Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
Tau deposits in astrocytes are frequently found in Alzheimer’s disease (AD) and other tauopathies. Since astrocytes do not express tau, the...
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A mathematical model on the propagation of tau pathology in neurodegenerative diseases
A system of partial differential equations is developed to study the spreading of tau pathology in the brain for Alzheimer’s and other...
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Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease
An unresolved question for the understanding of Alzheimer’s disease (AD) pathophysiology is why a significant percentage of amyloid-β (Aβ)-positive...
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ANU-ADRI scores, tau pathology, and cognition in non-demented adults: the CABLE study
BackgroundIt has been reported that the risk of Alzheimer’s disease (AD) could be predicted by the Australian National University Alzheimer Disease...
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The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation
Apolipoprotein E4 ( APOE4 ) is the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD), leading to earlier age of clinical onset...
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APP mediates tau uptake and its overexpression leads to the exacerbated tau pathology
Alzheimer’s disease (AD), as the most common type of dementia, has two pathological hallmarks, extracellular senile plaques composed of β-amyloid...
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Phosphorylation of Truncated Tau Promotes Abnormal Native Tau Pathology and Neurodegeneration
Abnormal posttranslational modifications of tau play important roles in mediating neurodegeneration in tauopathies including Alzheimer’s disease....
