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NLRP6 potentiates PI3K/AKT signalling by promoting autophagic degradation of p85α to drive tumorigenesis
The PI3K/AKT pathway plays an essential role in tumour development. NOD-like receptors (NLRs) regulate innate immunity and are implicated in cancer,...
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The role of NLRP6 in the development and progression of neurological diseases
The nervous system possesses the remarkable ability to undergo changes in order to store information; however, it is also susceptible to damage...
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Loss of NLRP6 expression increases the severity of intestinal injury after syngeneic hematopoietic stem cell transplantation
NLRP6 plays a crucial role in maintaining intestinal homeostasis by regulating the interaction between the intestinal mucosa and the microbiota....
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Decreased expression of the NLRP6 inflammasome is associated with increased intestinal permeability and inflammation in obesity with type 2 diabetes
BackgroundObesity-associated dysfunctional intestinal permeability contributes to systemic chronic inflammation leading to the development of...
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Physiological and pathophysiological functions of NLRP6: pro- and anti-inflammatory roles
The nucleotide-binding oligomerization and leucine-rich repeat receptor (NLR) protein family consists of important immune sensors that form...
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The important role of NLRP6 inflammasome in Pasteurella multocida infection
Pasteurella multocida ( P. multocida ) can cause severe respiratory disease in cattle, resulting in high mortality and morbidity. Inflammasomes are...
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NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer
Metastasis remains the primary cause of small cell lung cancer (SCLC)-related deaths. Growing evidence links tumor metastasis with a pre-metastatic...
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AIP1 suppresses neovascularization by inhibiting the NOX4-induced NLRP3/NLRP6 imbalance in a murine corneal alkali burn model
BackgroundApoptosis signal-regulating kinase 1-interacting protein 1 (AIP1) participates in inflammatory neovascularization induction. NADPH oxidase...
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NLRP6 modulates neutrophil homeostasis in bacterial pneumonia-derived sepsis
Bacterial pneumonia is a significant cause of morbidity, mortality, and health care expenditures. Optimum neutrophil recruitment and their function...
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NLRP6 contributes to inflammation and brain injury following intracerebral haemorrhage by activating autophagy
AbstractInflammation is a crucial factor contributing to secondary brain injury after intracerebral haemorrhage (ICH). NLRP6, a member of nod-like...
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Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation
The inflammasome NLRP6 plays a crucial role in regulating inflammation and host defense against microorganisms in the intestine. However, the...
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The NLRP6 inflammasome in health and disease
NACHT, LRR (leucine-rich repeat), and PYD (pyrin domain) domain-containing 6 (Nlrp6) is a member of the NLR (nucleotide-oligomerization domain-like...
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The interaction of inflammasomes and gut microbiota: novel therapeutic insights
Inflammasomes are complex platforms for the cleavage and release of inactivated IL-1β and IL-18 cytokines that trigger inflammatory responses against...
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An 8-gene predicting survival model of hepatocellular carcinoma (HCC) related to pyroptosis and cuproptosis
BackgroundThe study aimed to establish a prognostic survival model with 8 pyroptosis-and-cuproptosis-related genes to examine the prognostic effect...
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NLRP6 self-assembles into a linear molecular platform following LPS binding and ATP stimulation
NOD-like receptors (NLRs) localize in the cytosol to recognize intracellular pathogen products and initialize the innate immune response. However,...
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NLRP inflammasomes in health and disease
NLRP inflammasomes are a group of cytosolic multiprotein oligomer pattern recognition receptors (PRRs) involved in the recognition of...
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Upregulation of Intestinal NLRP6 Inflammasomes After Roux-en-Y Gastric Bypass Promotes Gut Immune Homeostasis
ObjectiveRoux-en-Y gastric bypass (RYGB) could affect immunological activity after surgery. We examined the role of RYGB on the NOD-like receptor...
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Identification and in vitro and in vivo validation of the key role of GSDME in pyroptosis-related genes signature in hepatocellular carcinoma
We used pyroptosis-related genes to establish a risk–score model for prognostic prediction of liver hepatocellular carcinoma (LIHC) patients. A total...
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Effects of NLRP6 in Cerebral Ischemia/Reperfusion (I/R) Injury in Rats
The NOD-like receptor protein 6 (NLRP6), an intracytoplasmic pattern recognition receptor in the nucleotide-binding domain, leucine-rich...
