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High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats
Obesity, associated with the intake of a high-fat diet (HFD), and anxiety are common among those living in modern urban societies. Recent studies...
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Extreme behavioural and psychological symptoms of dementia: a case study
BackgroundThe seven tiered behavioural and psychological symptoms of dementia (BPSD) model of service delivery has been used by inpatient units. The...
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Mutations associated with autism lead to similar synaptic and behavioral alterations in both sexes of male and female mouse brain
Autism spectrum disorder (ASD) is a neurodevelopmental disorder based on synaptic abnormalities. The estimated prevalence rate of male individuals...
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Immune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertility
We conducted a genome-wide association study in a large population of infertile men due to unexplained spermatogenic failure (SPGF). More than seven...
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Extreme conditioning session augments brain-derived neurotrophic factor in healthy novice participants: a pilot study
PurposeTo analyze the circulating serum levels of the brain-derived neurotrophic factor (BDNF) in novice participants submitted to an extreme...
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The maintenance of oocytes in the mammalian ovary involves extreme protein longevity
Women are born with all of their oocytes. The oocyte proteome must be maintained with minimal damage throughout the woman’s reproductive life, and...
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Extreme deviations from the normative model reveal cortical heterogeneity and associations with negative symptom severity in first-episode psychosis from the OPTiMiSE and GAP studies
There is currently no quantifiable method to predict long-term clinical outcomes in patients presenting with a first episode of psychosis. A major...
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Analysis of androgen receptor expression and activity in the mouse brain
Androgen deprivation therapy (ADT) is the core treatment for advanced prostate cancer (PCa), with a proven survival benefit. ADT lowers circulating...
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Extreme Y chromosome polymorphism corresponds to five male reproductive morphs of a freshwater fish
Loss of recombination between sex chromosomes often depletes Y chromosomes of functional content and genetic variation, which might limit their...
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Survey on extreme learning machines for outlier detection
In a two-class classification task, if the number of examples of one class (majority) is much greater than that of another class (minority), then the...
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Brains vs Brawn: Relative brain size is sexually dimorphic amongst weapon-bearing ruminants
AbstractHere, we investigate the relationship between relative brain size and sexual weapons in ruminants. In most cases, sexual weaponry is heavily...
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Environmental Impact on Semen Quality and Male Fertility
In recent years, a mounting evidence has highlighted a decline of semen qualitySemen quality and increase in male infertility. The alterations in... -
Functional Morphology of the Male Reproductive System
The reproductive organs of males comprised of primary reproductive organs (testes), excurrent ducts composed of rete testis, vasa efferentia,... -
Potential biomarkers in hypoglycemic brain injury
Oxidative stress is a major underlying mechanism in hypoglycemic brain injury. Several oxidative stress–related proteins were identified through...
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Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein
BackgroundUsing mouse genetic studies and systematic assessments of brain neuroanatomical phenotypes, we set out to identify which of the 30 genes...
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A regional brain volume–based age prediction model for neonates and the derived brain maturation index
ObjectiveTo develop a postmenstrual age (PMA) prediction model based on segmentation volume and to evaluate the brain maturation index using the...
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Extreme Low Temperature Safety
Due in part to the significant environmental conditions that a vessel and its crew are operating in, particular attention must be paid to the... -
Brain intrinsic magnetic susceptibility mapping depicts whole-brain functional connectivity balance of normal aging in lifespan
We hypothesized that brain normal aging maintains a balanced whole-brain functional connectivity (FC) in lifetime: some connections decline while...